Experimental prostatitis in nonhuman primates: II. Ascending acute prostatitis

Abstract

Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild-type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.

Macaque Models of Human Infectious Disease

“…For over 30 years, macaques have served as models to investigate the pathogenesis and treatment of experimental E. coli infection, including pyelonephritis (Roberts 1975), prostatitis (Neal et al 1990), bloody diarrhea (Kang et al 2001), and septic shock (Coalson et al 1979). Immunization with Shiga toxin liposome conjugates protected macaques against lethal doses of E. coli Shiga toxin (Suzaki et al 2002).…”

Prostate specific antigen and prostatitis II. PSA production and release kinetics in vitro

“…It is serotype 04. This organism has been used extensively in prostatitis research involving a nonhuman primate model of infection [6].…”

Influencia del tabaquismo en la resistencia bacteriana después de la profilaxis frente a infecciones urinarias recurrentes con antibiótico o con vacuna

“…Existen una serie de características que pueden servir para describir las ITU complicadas. La primera es que, al igual que las ITU no complicadas, casi siempre son de origen ascendente [40,41].…”

“…Otra excepción son los pacientes con infecciones miliares que comienzan en otro punto de entrada y son transportadas, hematógenamente hasta los riñones, siendo el prototipo de esta infección el Mycobacterium tuberculosis. Al principio, la E.coli tiende a provocar la primera infección en muchos casos [41], pero las infecciones subsecuentes pueden ser por otro microorganismo, a menudo con resistencias variables según el antibiograma.…”