Experimental Reimplantation Models

Khachatryan, Arbak; Tevosyan, Artur; Novoselskiy, David; Arakelyan, Gevorg; Yushkevich, Alexey; Nazarian, David Nazaretovich

doi:10.1007/978-3-030-73531-9_20

Cited by 1 publication

(1 citation statement)

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“…Today, rodents are considered models for reimplanting extremities and restoring blood vessels because their vascularization is homologous to the human finger [ 112 ]. For example, developing heterotrophic osteomyocutaneus flap transplant protocols in Lewis rats furthered our understanding of the mechanisms and pathways involved in the immune response underlying tissue transplant rejection [ 113 ].…”

Section: Animal Models and Their Application In Distinct Fields Of Cu...mentioning

confidence: 99%

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Domínguez-Oliva

Hernández-Ávalos

Martı́nez-Burnes

et al. 2023

Animals

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Animal research is considered a key element in advance of biomedical science. Although its use is controversial and raises ethical challenges, the contribution of animal models in medicine is essential for understanding the physiopathology and novel treatment alternatives for several animal and human diseases. Current pandemics’ pathology, such as the 2019 Coronavirus disease, has been studied in primate, rodent, and porcine models to recognize infection routes and develop therapeutic protocols. Worldwide issues such as diabetes, obesity, neurological disorders, pain, rehabilitation medicine, and surgical techniques require studying the process in different animal species before testing them on humans. Due to their relevance, this article aims to discuss the importance of animal models in diverse lines of biomedical research by analyzing the contributions of the various species utilized in science over the past five years about key topics concerning human and animal health.

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Section: Animal Models and Their Application In Distinct Fields Of Cu...mentioning

confidence: 99%