Experimental setup and the system performance for single-grid-based phase-contrast x-ray imaging (PCXI) with a microfocus x-ray tube

Lim, Hyunwoo; Park, Yeonok; Cho, Hyosung; Je, Uikyu; Hong, Dae-Ki; Park, Chulkyu; Woo, Tae Ho; Lee, Minsik; Chung, Nagkun; Kim, Jinwon; Kim, Jinguk

doi:10.1016/j.optcom.2015.03.028

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…However, some studies have reported contrasting findings. A previous study [ 34 ] reported that the internal information from a sample is not visible in low-energy images, which can be attributed to the fact that the scattering signals caused by the micro-structures in low-energy images are more prominent than that in high-energy images. Consequently, the scattering signals in phase-contrast X-ray images at a low energy result in noise, which can lead to the loss of detailed information from a sample.…”

Section: Discussionmentioning

confidence: 99%

Acquisition of a single grid-based phase-contrast X-ray image using instantaneous frequency and noise filtering

2022

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Background To obtain phase-contrast X-ray images, single-grid imaging systems are effective, but Moire artifacts remain a significant issue. The solution for removing Moire artifacts from an image is grid rotation, which can distinguish between these artifacts and sample information within the Fourier space. However, the mechanical movement of grid rotation is slower than the real-time change in Moire artifacts. Thus, Moire artifacts generated during real-time imaging cannot be removed using grid rotation. To overcome this problem, we propose an effective method to obtain phase-contrast X-ray images using instantaneous frequency and noise filtering. Result The proposed phase-contrast X-ray image using instantaneous frequency and noise filtering effectively suppressed noise with Moire patterns. The proposed method also preserved the clear edge of the inner and outer boundaries and internal anatomical information from the biological sample, outperforming conventional Fourier analysis-based methods, including absorption, scattering, and phase-contrast X-ray images. In particular, when comparing the phase information for the proposed method with the x-axis gradient image from the absorption image, the proposed method correctly distinguished two different types of soft tissue and the detailed information, while the latter method did not. Conclusion This study successfully achieved a significant improvement in image quality for phase-contrast X-ray images using instantaneous frequency and noise filtering. This study can provide a foundation for real-time bio-imaging research using three-dimensional computed tomography.

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Section: Discussionmentioning

confidence: 99%

Acquisition of a single grid-based phase-contrast X-ray image using instantaneous frequency and noise filtering

2022

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“…While the imaging was performed on ex vivo samples at a synchrotron facility, efforts are underway for developing in-lab small animal XPC imagers that could lead to longitudinal in vivo XPC imaging 7, 30, 44, 48 . Our findings, combined with studies showing in vitro imaging of hydrogel samples 2 and full live mice 7 with an in-lab XPC system indicate the significant potential for imaging of hydrogels in animals with micro-focus X-ray tube.…”

Section: Discussionmentioning

confidence: 99%

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

et al. 2015

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Three dimensional imaging techniques are needed for the evaluation and assessment of biomaterials used for tissue engineering and drug delivery applications. Hydrogels are a particularly popular class of materials for medical applications but are difficult to image in tissue using most available imaging modalities. Imaging techniques based on X-ray Phase Contrast (XPC) have shown promise for tissue engineering applications due to their ability to provide image contrast based on multiple X-ray properties. In this manuscript, we investigate the use of XPC for imaging a model hydrogel and soft tissue structure. Porous fibrin loaded poly(ethylene glycol) hydrogels were synthesized and implanted in a rodent subcutaneous model. Samples were explanted and imaged with an analyzer-based XPC technique and processed and stained for histology for comparison. Both hydrogel and soft tissues structures could be identified in XPC images. Structure in skeletal muscle adjacent could be visualized and invading fibrovascular tissue could be quantified. There were no differences between invading tissue measurements from XPC and the gold-standard histology. These results provide evidence of the significant potential of techniques based on XPC for 3D imaging of hydrogel structure and local tissue response.

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“…Compared with synchrotron radiation source, X-ray tube source is simpler, lower cost, much smaller and easier to obtain. So X-ray phase contrast imaging based on the X-ray tube is wildly used in laboratory imaging system [28,[33][34][35]. In 2003, Xiao et al reported a new type of laboratory system for XPCI, which is based on a nano-focused X-ray tube with a source size of 500 nm.…”

Section: Two-dimensional Microstructures Imaged By X-ray Tube Based Xpcimentioning

confidence: 99%

Microscopic identification of Chinese medicinal materials based on X-ray phase contrast imaging: from qualitative to quantitative

et al. 2016

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JINST 11 C07001phase contrast micro-CT for investigating the characteristic microstructures of CMMs. During this period, a variety of typical CMMs have been investigated, from two-dimensional (2D) radiography to three-dimensional (3D) micro-CT, from qualitative to quantitative. Taken together, these results verify that quantitative X-ray phase contrast micro-CT is a practical tool for the microscopic investigation of CMMs. Additionally, further efforts are being made to find the relationship between the microstructures' quantitative factors and active chemical components. At present, experimental results have demonstrated that the quality of CMMs can be evaluated directly via the quantitative information of their characteristic microstructures. K: Computerized Tomography (CT) and Computed Radiography (CR); X-ray radiography and digital radiography (DR)

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Experimental setup and the system performance for single-grid-based phase-contrast x-ray imaging (PCXI) with a microfocus x-ray tube

Cited by 11 publications

References 13 publications

Acquisition of a single grid-based phase-contrast X-ray image using instantaneous frequency and noise filtering

Acquisition of a single grid-based phase-contrast X-ray image using instantaneous frequency and noise filtering

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

Microscopic identification of Chinese medicinal materials based on X-ray phase contrast imaging: from qualitative to quantitative

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