Experimental Staphylococcal Folliculitis

O’Brien, John P.

doi:10.1001/archderm.1952.01530210085010

Cited by 9 publications

(2 citation statements)

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“…A different pathological approach of the ductal obstruction was proposed by O'Brien [161]. According to this author, the follicular opening, like the sweat pore, is surrounded by a ‘follicular keratin ring' made of concentric lamellated keratin.…”

Section: Comedogenesis: From the Horny Plug To The Biofilm Theorymentioning

confidence: 99%

“…In this view the obstruction is not inside the duct but is caused by the ring that surrounds it. Moreover, considering similarities between staphylococcal folliculitis and acne lesions that showed keratosis, infection and obstruction, he suggested that the initial lesion of acne, ‘obstructive in nature', located at the follicular ‘keratin ring' is caused by primary or secondary infection [161]. …”

Section: Comedogenesis: From the Horny Plug To The Biofilm Theorymentioning

confidence: 99%

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Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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Section: Comedogenesis: From the Horny Plug To The Biofilm Theorymentioning

confidence: 99%

Section: Comedogenesis: From the Horny Plug To The Biofilm Theorymentioning

confidence: 99%