Experimental strabismus surgery using triamcinolone: outcomes and effects on inflammatory response

Carvalho, Luis Eduardo Morato Rebouças de; Alves, Mílton Ruiz; Silva, Maria Antonieta Longo Galvão da; Vadas, Marcelo F. Gaal

doi:10.1590/s0004-27492007000200005

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…In an experimental study by De Carvalho and colleagues, 4 intraoperative triamcinolone showed a significant decrease of postoperative inflammatory response after strabismus surgery. However, there are complications associated with steroid use, particularly the increase in the intraocular pressure.…”

Section: Discussionmentioning

confidence: 93%

The use of amniotic membrane in reducing adhesions after strabismus surgery

Sheha

Casas

Hayashida

2009

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 93%

The use of amniotic membrane in reducing adhesions after strabismus surgery

Sheha

Casas

Hayashida

2009

Journal of American Association for Pediatric Ophthalmology and

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“…The reason of the intensification of the inflammation is that we do not know the exact degree of the inflammatory response of strabismus surgery performed in rabbits. De Carvalho et al [7] reported that there was only a minimal inflammatory response after a simple strabismus surgery in rabbits. Therefore, we intentionally enhanced the inflammation to verify the anti-inflammatory effect of the AM easily.…”

Section: Methodsmentioning

confidence: 99%

“…The tissues were processed for histological examinations through staining with hematoxylin eosin (HE) and Masson's trichrome (MT) to evaluate the severity of inflammation and the presence of fibrosis. These staining methods identify the muscular cell nuclei as blue-black, cytoplasm as red, staple fibers as red, and collagen as blue [7]. …”

Section: Methodsmentioning

confidence: 99%

Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery

Chun

Kim²,

Shin³

2013

Journal of Ophthalmology

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Purpose. The purpose of this study was to evaluate the efficacy of dried human amniotic membrane (AM) in reducing the postoperative inflammatory response and scarring after strabismus surgery. Methods. The inflammatory response at the extraocular muscle reattachment site was analyzed after superior rectus (SR) resection in 12 rabbits. Dried human AM (Ambiodry2) was applied between the resected SR muscle plane and Tenon's capsule of the left eyes of rabbits. As a control, the right eyes of rabbits underwent SR resection only. The surgeon randomly ordered which eye gets operated first during the experiment. Two weeks later, enucleation was performed. Six sagittal sections were made for each eye at the insertion of the SR muscle. The grade of postoperative inflammation and the presence of fibrosis were evaluated in histological examinations. Results. There was no statistically significant difference in the intensity of inflammation and fibrous proliferation between the eyes treated with dried human AM after SR resection and those treated with SR resection only. Conclusions. The use of dried human AM was not effective in controlling the postoperative inflammation and scarring in rabbit eyes after extraocular muscle surgery. However, this may be due to the devitalized dry preparation of human AM (Ambiodry2), which may have lost the expected anti-inflammatory and anti-scarring properties, and further studies on humans may be necessary.

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“…For this reason, in our surgical operations, we placed the stromal side of the amniotic membrane facing toward the tenon's capsule. Our surgical procedure was slightly different from the procedures used in previous studies [3][4][5][6]. Two sheets of AM under and over the EOM were sutured to the sclera so that both sheets of AM were stable after the surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Restrictions usually develop after excessive resections, intraconal fat violation or scar tissue formation, which result in postoperative adhesions [2]. Various approaches have been used to prevent the formation of postsurgical adhesions, including polyamide 6.6 (Supramid; Jackson, Alexandria, VA, USA), silicone sleeves, polyglactin 910 mesh, polypeptide sleeves, sodium hyaluronate, steroids, mitomycin C, 5 fluorouracil and Seprafilm (Genzyme, Cambridge, MA, USA) [3][4][5][6][7][8][9]. However, none of these approaches is widely used because of associated complications, unavailability or inconsistent results.…”

Section: Introductionmentioning

confidence: 99%