2023
DOI: 10.3390/ijms24076190
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Experimental Studies on the Thermal Properties and Decomposition Course of a Novel Class of Heterocyclic Anticancer Drug Candidates

Abstract: The experimental studies on the thermal properties and decomposition course of a novel class of potential anticancer drugs (1–5) containing in their heterobicyclic structures the asymmetrical triazine template were performed with the use of differential scanning calorimetry (DSC) and simultaneous thermogravimetry/differential scanning calorimetry (TG/DTG/DSC) coupled online with Fourier transform infrared spectroscopy (FTIR) and quadrupole mass spectrometry (QMS) in inert and oxidizing conditions. All the comp… Show more

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Cited by 2 publications
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“…This could be attributed to the breaking of C-N bonds (including the ones in amide bonds) which have been reported at the onset of 300 °C. 29,30 In HNH, a well-defined peak at 393 °C is observable on the DTG curve, with a mass loss rate of −0.5 °C min −1 , indicative of a second decomposition happening in this sample. Meanwhile, in LNH this reaction is merely a shoulder of a fast proceeding, almost linear decomposition happening in this sample from 85 to 520 °C.…”
Section: Nanoscalementioning
confidence: 87%
“…This could be attributed to the breaking of C-N bonds (including the ones in amide bonds) which have been reported at the onset of 300 °C. 29,30 In HNH, a well-defined peak at 393 °C is observable on the DTG curve, with a mass loss rate of −0.5 °C min −1 , indicative of a second decomposition happening in this sample. Meanwhile, in LNH this reaction is merely a shoulder of a fast proceeding, almost linear decomposition happening in this sample from 85 to 520 °C.…”
Section: Nanoscalementioning
confidence: 87%