Experimental Study of Bone Marrow Stem Cell Inducing Osteogenesis on SLA Titanium Mesh Surfac

Abstract

Abstract. Objective: Through animal experiments to understand medical titanium mesh in the sandblasting acid corrosion (SLA) before and after processing and surface coverage of BMSCs cell membrane after the effect of inducing osteogenesis, for medical titanium net covering the bone marrow stem cells after surface modification diaphragm local defect reconstruction of maxilla and form a bionic bone. Materials and methods: To observe the SLA titanium mesh surface morphology changes before and after processing; Making experimental rabbit BMSCs and culture cell cell membrane, According to the experimental steps and grouping plan will surface treatment before and after the experiment rabbit implanted with titanium mesh and cell membrane, after six months after feeding titanium mesh and the surface osteogenesis effect was observed and compared. Results: 1) Will be without surface treatment and after surface treatment of medical experimental rabbit implanted with titanium mesh directly, after take out the titanium mesh specimen observation, without surface treatment of the surface of the titanium mesh individual islands area is bone tissue osteogenesis effect is poorer, after surface treatment of titanium mesh is formed relatively complete bone tissue layer, but relatively weak bone tissue layer. 2) To the blanket in the diaphragm of BMSCs cells in medical titanium implant experimental animals, after take out the titanium mesh specimen observation, uncovered the cell membrane of titanium net, no matter whether it is for surface treatment, the surface osteogenesis effect are also covered the cell membrane of titanium mesh is poor.Conclusion: Bone marrow stem cell patch plays a decisive role in the process of titanium mesh inducing osteogenesis. Titanium mesh surface SLA processing only plays an auxiliary role. Therefore, the order from the best to the worst final effect of inducing osteogenesis is shown as follows: SLA processing + cell patch > no SLA processing + cell patch > SLA processing > no SLA processing.