Experimental Study of Negative Pressure Wound Therapy Combined with Platelet-Rich Fibrin for Bone-Exposed Wounds

Abstract

Aim: To evaluate the efficacy of negative pressure wound therapy (NPWT) combined with platelet-rich fibrin (PRF) in treating bone-exposed wounds and explore its possible mechanism. Materials & methods: A bone-exposed wound was created in a total of 32 healthy Sprague-Dawley rats, which were treated with either control, NPWT group, PRF group or both (N + P group). The bone-exposed area, skin contraction rate and granulation coverage and the level of growth factors in granulation tissue were determined on days 4, 7 and 10. Results: The N + P group showed significantly higher wound closure rate than that achieved with others respectively. Four factors were significantly higher in N + P group than in the other three groups. Conclusion: Combination of NPWT and PRF can repair bone-exposed wounds effectively and accelerate wound healing.

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

“…One study revealed that the osteogenic potential of MSCs can be modulated by mechanical stimulation. Mechanical cues and appropriate stiffness can promote in vitro and endochondral osseointegration and differentiation of MSCs 156 . Several in vitro and in vivo studies have demonstrated that bone regeneration can be accelerated by enhancing MSC proliferation, osteoblast differentiation, and osteogenesis-related cytokine expression through continuous or intermittent NPWT.…”