Experimental Study of the Effects of Nanodispersed Ceria on Wound Repair

Legonkova, O.A.; Ushakova, T. A.; Savchenkova, I. P.; Perova, N. V.; Belova, M. S.; Torkova, A. A.; Baranchikov, А. Е.; Иванова, О. С.; Korotaeva, A. I.; Иванов, В. К.

doi:10.1007/s10517-017-3624-2

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…NPs exert an anti-inflammatory response both in the blood plasma, as previously shown in chapter 3.3, and capsule tissue. Similar results were also obtained by Legon`kova et al and Gong et al in wound repair, where they showed that Ce-based nanomaterials stimulate the wound healing and epithelial regeneration process in the presence of lymphocyte-macrophage infiltration (Legonkova et al, 2017;Gong et al, 2022).…”

Section: Increase In Macrophage Recruitment After Np Treatment As Dem...supporting

confidence: 86%

Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats

Pais,

Papanikolaou,

Hoyos

et al. 2024

Front. Bioeng. Biotechnol.

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Background: Seroma formation is a common postoperative complication. Fibrin-based glues are typically employed in an attempt to seal the cavity. Recently, the first nanoparticle (NP)-based treatment approaches have emerged. Nanoparticle dispersions can be used as tissue glues, capitalizing on a phenomenon known as ‘nanobridging’. In this process, macromolecules such as proteins physically adsorb onto the NP surface, leading to macroscopic adhesion. Although significant early seroma reduction has been shown, little is known about long-term efficacy of NPs. The aim of this study was to assess the long-term effects of NPs in reducing seroma formation, and to understand their underlying mechanism.Methods: Seroma was surgically induced bilaterally in 20 Lewis rats. On postoperative day (POD) 7, seromas were aspirated on both sides. In 10 rats, one side was treated with NPs, while the contralateral side received only NP carrier solution. In the other 10 rats, one side was treated with fibrin glue, while the other was left untreated. Seroma fluid, blood and tissue samples were obtained at defined time points. Biochemical, histopathological and immunohistochemical assessments were made.Results: NP-treated sides showed no macroscopically visible seroma formation after application on POD 7, in stark contrast to the fibrin-treated sides, where 60% of the rats had seromas on POD 14, and 50% on POD 21. At the endpoint (POD 42), sides treated with nanoparticles (NPs) exhibited significant macroscopic differences compared to other groups, including the absence of a cavity, and increased fibrous adhesions. Histologically, there were more macrophage groupings and collagen type 1 (COL1) deposits in the superficial capsule on NP-treated sides.Conclusion: NPs not only significantly reduced early manifestations of seroma and demonstrated an anti-inflammatory response, but they also led to increased adhesion formation over the long term, suggesting a decreased risk of seroma recurrence. These findings highlight both the adhesive properties of NPs and their potential for clinical therapy.

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Section: Increase In Macrophage Recruitment After Np Treatment As Dem...supporting

confidence: 86%

Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats

Pais,

Papanikolaou,

Hoyos

et al. 2024

Front. Bioeng. Biotechnol.

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“…Today, cerium oxide nanoparticles (nanoceria, CeNPs) are considered one of the most promising metal oxide nanobiomaterials [19][20][21][22]: pristine (bare) or ligand-stabilized CeNPs are well-known therapeutic agents in regenerative medicine [19][20][21][22] and tissue engineering [22]; they stimulate the proliferation of cells in vitro [21,23,24] and accelerate the healing of lesions in vivo [25], thus reshaping perspectives for wound therapy [26,27]. CeNPs have been shown to be the first inorganic mitogen: in 2019, Popov et al reported experimental evidence for the mitogenic action of CeNPs in the regeneration of a whole organism, freshwater flatworms [28].…”

Section: Multifaceted Biomedical Applications Of Cerium Oxide Nanoparmentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

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The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

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“…CNPs as bioactive materials have been introduced as remarkable therapeutics for skin tissue repair and regeneration [ 99 , 100 ]. Nanoceria is recognized as a stimulator of fibroblast proliferation in vitro [ 101 , 102 ] and an accelerator of the healing of model lesions in vivo [ 103 , 104 ]. Having unique antioxidant, anti-inflammatory, and antibacterial properties, CNPs have attracted much attention for use in the treatment of both acute (e.g., burns) and chronic (diabetic wounds) skin lesions.…”

Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Experimental Study of the Effects of Nanodispersed Ceria on Wound Repair

Abstract: We studied the effects of nanodispersed ceria on wound healing in vitro and in vivo. It was found that cerium dioxide stimulated wound healing, which manifested in shrinkage of burn wound area (by 1.5 times) and intensification (by 2.4 times) marginal epithelialization.

Cited by 10 publications

References 6 publications

Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats

Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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