Experimental Study on Acupuncture Activating the Gonadotropin-releasing Hormone Neurons in Hypothalamus

Wang, Shaojun; Zhu, Bing; Ren, Xiubao; Tan, Lian-Hong

doi:10.1016/s0254-6272(10)60009-x

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…CV4 [8] is located on the Bladder Meridian of Foot-Taiyang. As is described in Zhenjiu Zisheng Jing , Guanyuan acupoint (CV4) can treat most diseases related to failure of urination.…”

Section: Discussionmentioning

confidence: 99%

Moxibustion Therapy at CV4 Prevents Postoperative Dysuria after Procedure for Prolapse and Hemorrhoids

Bian

Lin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the intervention methods of the patients with dysuria after performing the procedure for prolapse and hemorrhoids (PPH). Methods. 100 cases with hemorrhoids were randomly divided into experimental and control groups. The control group received routine nursing care. As comparison, the experimental group, on the basis of conventional care, was treated with moxa roll moxibustion 1 hour after the operation for 30 minutes. The autonomous urination within 1 h, 2 h, 4 h, 6 h, and 8 h after operation and the catheterization rate 8 h after operation of two groups of patients were observed. Results. The median time of autonomous urination of control group (8 h) was significantly greater than that of the experimental group (6 h) (P < 0.001). Cox regression analysis showed that the moxibustion therapy was positively correlated with automatic micturition in the patients after PPH. The probability of automatic micturition in the experimental group was 2.032 times that in the control group (RR = 2.032, 95% CI: 1.278~3.230). The catheterization rate of control group (38%) was significantly higher than that of the experimental group (10%) (P < 0.001). Conclusion. The Guanyuan acupoint moxibustion can prevent dysuria after PPH and reduce the urethral catheterization.

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“…CV4 [8] is located on the Bladder Meridian of Foot-Taiyang. As is described in Zhenjiu Zisheng Jing , Guanyuan acupoint (CV4) can treat most diseases related to failure of urination.…”

Section: Discussionmentioning

confidence: 99%

Moxibustion Therapy at CV4 Prevents Postoperative Dysuria after Procedure for Prolapse and Hemorrhoids

Bian

Lin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Previous studies suggested that electro-acupuncture on Sanyinjiao (SP6) and Zusanli (ST36) could modulate homeostasis of the hypothalamic GnRH level in physiologic rats [17]. Wang et al [26] found that acupuncture on the acupoints located at the same neural segment with the reproductive organ, such as Guanyuan (CV4) point and Shenshu (BL23) point that we used in the present study, could activate GnRH neurons in the hypothalamus. The present results showed that hypothalamic GnRH mRNA expression declined in both the PM1 group and the PM3 group compared to the model group, but no significant change was found in the PM2 group (p = 0.068).…”

Section: Discussionmentioning

confidence: 51%

The Protective Effect of Pre-Moxibustion on Reproductive Hormones Profile of Rats with <b><i>Tripterygium</i></b> Glycosides-Induced Ovarian Damage

et al. 2020

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Background: Acupuncture and moxibustion have been proven to be conducive to improving the ovarian reserve. However, the mechanism of pre-moxibustion on Tripterygium glycosides (TG)-induced ovarian damage has not been previously reported. Method: Female rats were randomly divided into 5 groups: control, model (75 mg/kg TG, 14 days), preventive moxibustion 1 (PM1, receiving moxibustion for 4 weeks before TG administration), preventive moxibustion 2 (PM2, receiving moxibustion for 2 weeks before TG administration and another 2 weeks during TG administration), and preventive moxibustion 3 (PM3, receiving 4 weeks of moxibustion during TG administration). The estrous cycle of the animal was recorded after TG administration. Rats were sacrificed 14 days after TG administration. The reproductive hormones profiles in serum, ovary, and hypothalamic tissues were analyzed. Result: Pre-moxibustion could revert abnormal estrous cycles, relieve follicle damage, and improve abnormal secretion of reproductive hormones resulting from ovarian damage. However, both PM2 and PM3 were more effective than PM1. In addition, PM2 disclosed more advantages in regulating reproductive hormones abnormalities, while PM3 performed better in follicular development. Conclusion: In combination, the findings of this study suggest that pre-moxibustion is effective in protecting the ovary from damage in TG-induced ovarian damage rats. But different time points correspond to different modulation targets and mechanisms.

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“…Our study focused on symptomatic improvement using validated questionnaires for a more robust assessment of change. Nonetheless, some rat model studies by Wang et al33, 34 evaluated hypothalamic function after activation by acupuncture and showed increased electrical activity of excitatory neurons related to stimulation of sexual arousal. Although we did not use an animal model, our population included reproductive-age women similar to the research of Wang et al and our subjects reported increased sexual arousal.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture in Premenopausal Women With Hypoactive Sexual Desire Disorder: A Prospective Cohort Pilot Study

et al. 2016

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IntroductionFemale sexual dysfunction affects up to 43% of women in the United States and hypoactive sexual desire disorder (HSDD) is the most common type; however, we lack treatment options showing improvement for this condition.AimsTo investigate whether acupuncture therapy could improve HSDD.MethodsPremenopausal women with a primary diagnosis of HSDD were included in a single-arm prospective pilot study that was approved by the institutional review board. After providing informed consent, subjects completed validated questionnaires. Participants underwent 25-minute twice-weekly acupuncture sessions for 5 weeks with one certified acupuncturist. Questionnaires were completed again 6 weeks after onset of treatment.Main Outcome MeasuresBased on a statistically significant change in the desire domain of the Female Sexual Function Index from 2.0 (at baseline) to 2.4 (after intervention with a specialist) in our population of patients diagnosed with HSDD, a sample of 13 was determined, with 90% power and α 0.05.ResultsFifteen women were enrolled and 13 completed the study. Mean age was 36.9 ± 11.4 years. Most were white (n = 9, 60%), heterosexual (n = 15, 100%), and non-smokers (n = 14, 93%). Most were sexually active more than four times per month (n = 8, 53%) and none had a history of sexual abuse (n = 15, 100%). Participants received a mean acupuncture needle application of 17 ± 2 at each session. Sexual function improved after intervention, particularly desire (2.1 ± 0.6 to 3.3 ± 1.2, P < .0001), arousal (P < .0001), lubrication (P = .03), and orgasm (P = .005).ConclusionIn this cohort of premenopausal women with HSDD, 5 weeks of acupuncture therapy was associated with significant improvements in sexual function, particularly desire. This supports a role for acupuncture as a therapeutic option for women with low desire.

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Experimental Study on Acupuncture Activating the Gonadotropin-releasing Hormone Neurons in Hypothalamus

Cited by 13 publications

References 10 publications

Moxibustion Therapy at CV4 Prevents Postoperative Dysuria after Procedure for Prolapse and Hemorrhoids

Moxibustion Therapy at CV4 Prevents Postoperative Dysuria after Procedure for Prolapse and Hemorrhoids

The Protective Effect of Pre-Moxibustion on Reproductive Hormones Profile of Rats with <b><i>Tripterygium</i></b> Glycosides-Induced Ovarian Damage

Acupuncture in Premenopausal Women With Hypoactive Sexual Desire Disorder: A Prospective Cohort Pilot Study

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