Experimental study on antiviral activity of silicone oil in vitro

Yan, Hua; Li, Jun

doi:10.1007/s00417-008-0857-9

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Besides this therapeutic use of silicone oil endotamponade, some authors suggest that initially using a prophylactic silicone oil endotamponade during vitrectomy could lead to better overall results in the treatment of retinal necrosis [31]. However, this conclusion is definitely limited by the small sample size due to the rarity of the disease but could be supported by the finding that silicone oil has an antiviral effect in vitro [32]. …”

Section: Redetachment Rates and Other Findings After Oil Removalmentioning

confidence: 70%

“…The effect of laser treatment is still controversial, but retinal detachment is seen less frequently after vitrectomy, which could be due to removal of vitreous traction on the weakened retina. Several groups reporting small case series have found high anatomical success rates of up to 100% for vitrectomy with silicone oil endotamponade for retinal detachment secondary to acute retinal necrosis, but only little functional recovery [27,28,29,30,31,32]. Besides this therapeutic use of silicone oil endotamponade, some authors suggest that initially using a prophylactic silicone oil endotamponade during vitrectomy could lead to better overall results in the treatment of retinal necrosis [31].…”

Section: Redetachment Rates and Other Findings After Oil Removalmentioning

confidence: 99%

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Long-Lasting Endotamponades in Vitreoretinal Surgery

Wagenfeld

Zeitz²,

Skevas³

et al. 2010

Ophthalmologica

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In modern vitreoretinal surgery, a variety of long-lasting endotamponades is available. These endotamponades differ in physical and chemical properties and their usage is based on certain pathological and surgical considerations. With modern endotamponades the treatment and prognosis for some severe diseases of the posterior segment was improved. Besides these supportive features of new endotamponades, the surgeon has to keep in mind that certain steps, like a complete removal of the vitreous and of any traction, are crucial for the success of an operation and that the most supportive step for the retina is complete endotamponade. This review gives an overview of longlasting endotampoandes in vitreoretinal surgery and of the indications for their usage.

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Section: Redetachment Rates and Other Findings After Oil Removalmentioning

confidence: 70%

Section: Redetachment Rates and Other Findings After Oil Removalmentioning

confidence: 99%

Long-Lasting Endotamponades in Vitreoretinal Surgery

Wagenfeld

Zeitz²,

Skevas³

et al. 2010

Ophthalmologica

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“…Silicone oil has a longer duration owing to its lower density and higher surface tension than water 77 . Additionally, studies have shown that silicone oil can inhibit the growth of residual pathogenic bacteria in the eye 78,79 …”

Section: Resultsmentioning

confidence: 99%

Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

Yan

Yang

et al. 2022

J Evidence Based Medicine

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Severe mechanical ocular trauma with no light perception (NLP) predicts a poor prognosis of visual acuity and enucleation of the eyeball. Since the innovative treatment concept of exploratory vitreoretinal surgery has developed and treatment technology has advanced, the outcomes of severe ocular trauma treatment in NLP patients have greatly improved. However, there remains a lack of unified standards for the determination, surgical indication, and timing of vitrectomy in NLP eye treatment. To address these problems, we aimed to create evidence‐based medical guidelines for the diagnosis, treatment, and prognosis of mechanical ocular trauma with NLP. Sixteen relevant recommendations for mechanical ocular trauma with NLP were obtained, and a consensus was reached. Each recommendation was explained in detail to guide the treatment of mechanical ocular trauma associated with NLP.

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“…For proving the antimicrobial and antiviral activity of silicone oil, we have performed two experiments, including an experimental study on antimicrobial activity of silicone oil in vitro and experimental study on antiviral activity of silicone oil in vitro (4,5). In the experimental study on antimicrobial activity of silicone oil in vitro, the antiviral activity of silicone oil against herpes simplex virus-1 (HSV-1) in vitro was studied.…”

Section: Experimental Evidence Of Antiviral and Antimicrobial Activitmentioning

confidence: 99%

Experimental study on antiviral activity of silicone oil in vitro

Abstract: Silicone oil has an antiviral function against HSV-1. The antiviral effect of silicone oil is correlated with concentration of virus.

Cited by 9 publications

References 7 publications

Long-Lasting Endotamponades in Vitreoretinal Surgery

Long-Lasting Endotamponades in Vitreoretinal Surgery

Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

The Equivocal Role of Silicone Oil in the Treatment of Traumatic Endophthalmitis

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