In order to study the blasting effect and the damage to the rock mass when the cutting seam cartridge is eccentrically and uncoupled. The ANSYS/LS-DYNA® nonlinear dynamic platform was used to simulate the blasting effect of five eccentric uncoupled coefficients on the cutting seam cartridge, and the crack growth process under the condition of complete eccentricity was simulated. By comparing and analyzing the stress of measuring points in the direction of cutting seam, vertical cutting seam direction, and circumferential cutting seam pipe under different working conditions. It is concluded that the effect of detonation products is affected by the wrapping property of the cutting seam pipe and the eccentric uncoupled coefficient. With the increase of the eccentric uncoupled coefficient, the load distribution presents obvious non-uniformity. The pressure on the uncoupled side of the blasthole is smaller than that on the coupled side, and the peak time of the uncoupled side also lags behind that on the coupled side. When the eccentric uncoupled coefficient is 1, the peak pressure on the coupled side is 5.78 times that of the uncoupled side, and the explosive stress field is biased toward the coupled side. The existence of the cutting seam pipe causes stress concentration at the opening, which enhances the guiding effect of the initial crack, and the stress in the non-cutting seam direction is buffered. Therefore, the eccentric arrangement of the cutting seam pipe determines the formation of the initial crack and the subsequent blasting effect. When the cutting seam cartridge is arranged eccentrically and uncoupled, it will cause under-excavation at the connection direction of blasthole, which will cause less disturbance to the rock mass on the uncoupled side. If the retaining side rock mass is on the coupled side in actual blasting, the eccentric uncoupled arrangement will cause greater over-excavation and damage. Therefore, it is necessary to avoid this situation as far as possible and provide better guidance for the actual construction.