Experimental Study on Embryo Skeletal Development to Postnatal Growth Process of Rabbit Thighbone

Abstract

Bone forming phenomenon is an exquisitely genetic programmed and dynamic process that occur from early embryo skeletal development to postnatal growth and culminating in the formation of highly variable and complex but perfect optimized structures. In this study the high resolution imaging techniques such as computerized tomography (CT) is used to obtain quantitative information about the progressive changes in three-dimensional (3D) skeletal morphology and density of rabbit thighbone during early embryo skeletal development to postnatal growth. Then the changes of the thighbone volume, shape and density during the bone growth process are evaluated by using the 3D images reconstruction method, and the growing direction of the thighbone structure is also evaluated. The effects of genetic and environmental complications to optimized skeletal patterns of bone are discussed.

Experimental Observation of the Skeletal Adaptive Repair Mechanism and Bionic Topology Optimization Method

“…Jia et al [12] generalized "iBone" model and applied this model to bone formation and resorption process under different boundary conditions; Geni and Kikuchi [13] applied this "iBone" model to shape optimization of Metal Welded Bellows Seal problems. Mamatrozi et al [14] and Mahemuti et al [15] observe skeletal morphology, the distributions of bone density, and volume of the thighbone by using the CT data from the experiment. Mamatjan et al [16] propose selfrepairing process of bone defect and real cross-type relations between the normalized bone mass volumes of enamel bone and spongy bone are observed.…”