The horizontal drop film evaporator is a key component of the mechanical vapor recompression crystallization system, which can be used to evaporate effluent and recycle secondary vapor energy. However, the properties of heat transfer and flow of the salty effluent sprayed external of the horizontal drop film evaporation tube are obviously different from that of ordinary water. We established a 3D model for a horizontal drop film evaporator in the system, and water and sodium sulfate mixture were manufactured to reproduce the real salty effluent. By applying the VOF (volume of fluid) model, the liquid-gas interface of a salty effluent spray drop film formed on a horizontal tube in the evaporator was traced. The impacts of various heat flux, sodium sulfate content, spray density, and temperature on the local Nusselt number were studied, and a dimensionless correlation was established. The results showed that the effect of surface tension cannot be negligible; as the sodium sulfate content rises, the local Nusselt number declines in the thermal developing region; as the spray temperature and density rises, the local Nusselt number rises, which was largely independent of the heat flux in the thermal developing region.