Experimental study on in vivo optical and radionuclide imaging in small animals

Autiero, Maddalena; Celentano, Luigi; Cozzolino, Rosanna; Laccetti, Paolo; Marotta, Maria; Mettivier, Giovanni; Montesi, M.C.; Riccio, Patrizia; Roberti, G.; Russo, Paolo

doi:10.1109/tns.2004.843095

Cited by 24 publications

(10 citation statements)

References 16 publications

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“…Hence, unless indicated, raw image data are displayed for this detector, i.e., without applying any pixel equalization or pixel correction procedures. This detector is the basic unit of a dedicated system for small animal planar 51,79 and SPECT imaging. [49][50][51] The dark noise of this detector-in the operating condi-tions of this study-is of the order of 10 −5 cps/ pixel, i.e., less than 1 cps over the whole array.…”

Section: Iib2 the University And Infn Napoli Cdte Gamma Cameramentioning

confidence: 99%

Imaging performance comparison between a scintillator based and a CdTe semiconductor based photon counting compact gamma camera

et al. 2009

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The authors report on the performance of two small field of view, compact gamma cameras working in single photon counting in planar imaging tests at 122 and 140 keV. The first camera is based on a LaBr3: Ce scintillator continuous crystal (49 x 49 x 5 mm3) assembled with a flat panel multianode photomultiplier tube with parallel readout. The second one belongs to the class of semiconductor hybrid pixel detectors, specifically, a CdTe pixel detector (14 x 14 x 1 mm3) with 256 x 256 square pixels and a pitch of 55 microm, read out by a CMOS single photon counting integrated circuit of the Medipix2 series. The scintillation camera was operated with selectable energy window while the CdTe camera was operated with a single low-energy detection threshold of about 20 keV, i.e., without energy discrimination. The detectors were coupled to pinhole or parallel-hole high-resolution collimators. The evaluation of their overall performance in basic imaging tasks is presented through measurements of their detection efficiency, intrinsic spatial resolution, noise, image SNR, and contrast recovery. The scintillation and CdTe cameras showed, respectively, detection efficiencies at 122 keV of 83% and 45%, intrinsic spatial resolutions of 0.9 mm and 75 microm, and total background noises of 40.5 and 1.6 cps. Imaging tests with high-resolution parallel-hole and pinhole collimators are also reported.

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Section: Iib2 the University And Infn Napoli Cdte Gamma Cameramentioning

confidence: 99%

Imaging performance comparison between a scintillator based and a CdTe semiconductor based photon counting compact gamma camera

et al. 2009

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“…Improved production processes will make available higher z detector materials such as GaAs and CdTe, increasing the functionality of Medipix by expanding its useful range to higher, diagnostic energies (>100keV) 23,26 .…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic biomedical imaging with the Medipix2 detector

Melzer

Cook

Butler

et al. 2008

Australas. Phys. Eng. Sci. Med.

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This study confirms that the Medipix2 x-ray detector enables spectroscopic bio-medical plain radiography. We show that the detector has the potential to provide new, useful information beyond the limited spectroscopic information of modern dual-energy computed tomography (CT) scanners. Full spectroscopic 3D-imaging is likely to be the next major technological advance in computed tomography, moving the modality towards molecular imaging applications. This paper focuses on the enabling technology which allows spectroscopic data collection and why this information is useful. In this preliminary study we acquired the first spectroscopic images of human tissue and other biological samples obtained using the Medipix2 detector. The images presented here include the clear resolution of the 1.4mm long distal phalanx of a 20 week old miscarried foetus, showing clear energy-dependent variations. The opportunities for further research using the forthcoming Medipix3 detector are discussed and a prototype spectroscopic CT scanner (MARS, Medipix All Resolution System) is briefly described.

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“…Collaboration at CERNprovided the γ-ray head for planar and SPECT small animal imaging system [43][44][45][46][47] and also for a thermal neutron detector system [48] and for electron imaging [49,50]. Preliminary results of this work have been reported in Ref.…”

Section: Introductionmentioning

confidence: 94%