High liquid limit soil has unfavorable engineering geological characteristics, such as strong disintegration, dry shrinkage and easy cracking, and easy uplift when encountering water, which will cause various problems to the engineering. At present, the relationship between the physical and mechanical properties of high liquid limit soil and the characteristics of water-soil interaction is still not clear enough. In this study, the high liquid limit soil of Zhanjiang Avenue was selected to explore the influence of different ratios of three kinds of industrial waste residues (blast furnace slag, carbide slag, and tailing sand) on the high liquid limit soil. Aiming at the common adverse engineering geological phenomena of high liquid limit soil, such as easy disintegration, dry shrinkage crack, and easy uplift in water, the effects of different industrial waste residues on the water-soil interaction characteristics of high liquid limit soil are explored through disintegration and crack tests. In addition, the effects of different kinds and ratios on the free expansion rate, pH, unconfined compressive strength, and shear strength parameters of high liquid limit soil were studied. The improvement mechanism of different industrial waste residues on the engineering properties of high liquid limit soil is discussed in terms of mineral composition and microstructure. Based on the experimental results of this study and considering the cost and engineering practice, it is suggested that the modified carbide slag optimal ratio of high liquid limit soil of Zhanjiang Avenue is 8%. The results can provide certain guidance for the improvement and application of different industrial waste residues on high liquid limit soil to achieve the effect of sustainable development.