Experimental Transmission of Bighorn Sheep Sinus Tumors to Bighorn Sheep (<i>Ovis canadensis canadensis</i>) and Domestic Sheep

Fox, Karen A.; Wootton, Sarah K.; Marolf, Angela J.; Rouse, Natalie; LeVan, Ivy K.; Spraker, Terry R.; Miller, M.; Quackenbush, Sandra L.

doi:10.1177/0300985816634810

Cited by 7 publications

(5 citation statements)

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“…Although not examined in this study, transmissible sinus tumors have also recently been discovered in bighorn sheep and are associated with increased shedding of Pasteurellaceae and M . ovipneumoniae [ 61 , 62 ]. It is hypothesized that sinus tumors exacerbate upper respiratory tract infections and increase pathogen transmission.…”

Section: Discussionmentioning

confidence: 99%

Respiratory pathogens and their association with population performance in Montana and Wyoming bighorn sheep populations

et al. 2018

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Respiratory disease caused by Mycoplasma ovipneumoniae and Pasteurellaceae poses a formidable challenge for bighorn sheep (Ovis canadensis) conservation. All-age epizootics can cause 10–90% mortality and are typically followed by multiple years of enzootic disease in lambs that hinders post-epizootic recovery of populations. The relative frequencies at which these epizootics are caused by the introduction of novel pathogens or expression of historic pathogens that have become resident in the populations is unknown. Our primary objectives were to determine how commonly the pathogens associated with respiratory disease are hosted by bighorn sheep populations and assess demographic characteristics of populations with respect to the presence of different pathogens. We sampled 22 bighorn sheep populations across Montana and Wyoming, USA for Mycoplasma ovipneumoniae and Pasteurellaceae and used data from management agencies to characterize the disease history and demographics of these populations. We tested for associations between lamb:ewe ratios and the presence of different respiratory pathogen species. All study populations hosted Pasteurellaceae and 17 (77%) hosted Mycoplasma ovipneumoniae. Average lamb:ewe ratios for individual populations where both Mycoplasma ovipneumoniae and Pasteurellaceae were detected ranged from 0.14 to 0.40. However, average lamb:ewe ratios were higher in populations where Mycoplasma ovipneumoniae was not detected (0.37, 95% CI: 0.27–0.51) than in populations where it was detected (0.25, 95% CI: 0.21–0.30). These findings suggest that respiratory pathogens are commonly hosted by bighorn sheep populations and often reduce recruitment rates; however ecological factors may interact with the pathogens to determine population-level effects. Elucidation of such factors could provide insights for management approaches that alleviate the effects of respiratory pathogens in bighorn sheep. Nevertheless, minimizing the introduction of novel pathogens from domestic sheep and goats remains imperative to bighorn sheep conservation.

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Section: Discussionmentioning

confidence: 99%

Respiratory pathogens and their association with population performance in Montana and Wyoming bighorn sheep populations

et al. 2018

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“…Clinically, domestic sheep and goats affected by ENA have abundant seromucinous nasal discharge. Similarities between ENA and bighorn sheep sinus tumors include the presence of seromucinous nasal discharge clinically, the gross finding of a soft white mass in the sinus cavity, and classification of some masses as adenocarcinoma [ 24 , 26 ]. Additionally, the inflammatory nasal polyps often associated with ENA share characteristics with the hyperplastic masses described here for bighorn sheep, although in bighorn sheep the sinus tumors is a diffuse thickening of the sinus lining and not a discrete polypoid mass.…”

Section: Discussionmentioning

confidence: 99%

Full-length genome sequence analysis of enzootic nasal tumor virus isolated from goats in China

Zhang

Jing

et al. 2017

Virol J

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BackgroundEnzootic nasal tumor virus (ENTV) is a betaretrovirus of sheep (ENTV-1) and goats (ENTV-2) associated with neoplastic transformation of epithelial cells of the ethmoid turbinate. Confirmation of the role of ENTV in the pathogenesis of enzootic nasal adenocarcinoma (ENA) has yet to be resolved due to the inability to culture the virus. Very little is known about the prevalence of this disease, particularly in China.MethodsTo evaluate the genetic diversity of ENTV-2 from Shaanxi province of China, the complete genome sequence of four isolates from Shaanxi province was determined by RT-PCR. These sequences were analyzed to evaluate their genetic relatedness with other small ruminant betaretroviruses. Phylogenetic analyses based on the gag gene and env gene were performed.ResultsThe ENTV-2-Shaanxi1 genome shared 97.0% sequence identity with ENTV-2-SC (accession number HM104174.1), and 89.6% sequence identity with the ENTV-2 sequences (accession number AY197548.1). ENTV-2 is closely related to the ENTV-1 and jaagsiekte retrovirus (JSRV). The main sequence differences between these viruses reside in LTR, two small regions of Gag, Orf-x, and the transmembrane (TM) region of Env. A stretch of 6 consecutive proline residues exists in VR1 of the ENTV-2-Shaanxi1 ~ 4 isolates. All the ENTV-2-Shaanxi isolates have the YXXM motif in the cytoplasmic tail of the Env. Phylogenetic analysis by nucleotide sequences showed that ENTV-2-Shaanxi1 ~ 4 isolates were closest related to two ENTV-2 isolates published in NCBI, especially with ENTV-2-SC strain.ConclusionsThis finding indicates that ENA most likely was introduced to Shaanxi province by the movement of contaminated goats from other areas in China. This study adds to understand the circulation, variation and distribution of ENTV-2, and may prove beneficial in future control or eradication programmes.

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“…Recently, a transmissible sinus tumor has been identified (Fox et al, 2011(Fox et al, , 2016) that is associated with co-infection by M. ovipneumoniae, and may contribute to chronic shedding of that pathogen (Fox et al, 2015). Adult females that persistently carry and chronically shed M. ovipneumoniae appear to be an important mechanism causing persistent juvenile mortality .…”

Section: Disease and Restorationmentioning

confidence: 99%

Advances in the Conservation of Large Terrestrial Mammals

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Experimental Transmission of Bighorn Sheep Sinus Tumors to Bighorn Sheep (Ovis canadensis canadensis) and Domestic Sheep

Cited by 7 publications

References 6 publications

Respiratory pathogens and their association with population performance in Montana and Wyoming bighorn sheep populations

Respiratory pathogens and their association with population performance in Montana and Wyoming bighorn sheep populations

Full-length genome sequence analysis of enzootic nasal tumor virus isolated from goats in China

Advances in the Conservation of Large Terrestrial Mammals

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