Experimentalle studien an säugethieren über das elektrocardiogramm

Hering, H. E.

doi:10.1007/bf02659994

Cited by 69 publications

(27 citation statements)

References 2 publications

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“…T-wave alternans refers to primary T-wave fluctuations as opposed to T-wave fluctuations secondary to electrical alternans totalis (alternans of all ECG components, such as in pericardial effusion) or QRS alternans. Visible TWA was first reported in the early 1900s during tachycardia and ischemia in remarkable observations by Hering (18) and Sir Thomas Lewis (19). Subsequently, visible TWA of increasing subtlety (Figs.…”

Section: Phenomenology and History Of Twamentioning

confidence: 97%

T-Wave Alternans and the Susceptibility to Ventricular Arrhythmias

Narayan

2006

Journal of the American College of Cardiology

306

281

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T-wave alternans (TWA) reflects beat-to-beat fluctuations in the electrocardiographic T-wave, and is associated with dispersion of repolarization and the mechanisms for sudden cardiac arrest (SCA). This review examines the bench-to-bedside literature that, over decades, has linked alternans of repolarization in cellular, whole-heart, and human studies with spatial dispersion of repolarization, alternans of cellular action potential, and fluctuations in ionic currents that may lead to ventricular arrhythmias. Collectively, these studies provide a foundation for the clinical use of TWA to reflect susceptibility to ventricular arrhythmias in several disease states. This review then provides a contemporary evidence-based framework for the use of TWA to enhance risk stratification for SCA, identifying populations for whom TWA is best established, those for whom further studies are required, and areas for additional investigation.

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Section: Phenomenology and History Of Twamentioning

confidence: 97%

T-Wave Alternans and the Susceptibility to Ventricular Arrhythmias

Narayan

2006

Journal of the American College of Cardiology

306

281

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“…Straub's experiments led that investigator to believe that the weak beat is initiated from a smaller volume but a higher pressure and that this was attributable to incomplete metabolic recovery from the previous strong beat (10). A third view (11)(12)(13)(14)(15) holds that there is an alternate failure of contraction of certain myocardial segments, a view which is still current (16,17).…”

mentioning

confidence: 99%

The Dynamics of Pulsus Alternans: Alternating End-Diastolic Fiber Length as a Causative Factor

Mitchell¹,

Sarnoff²,

Sonnenblick³

1963

J. Clin. Invest.

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“…This pattern was first described by Herring [20] in 1909, and was initially thought to be of little significance. It was subsequently observed in a surprisingly wide variety of clinical and experimental conditions associated with ventricular arrhythmias, including acute MI [21], electrolyte imbalances, and long QT syndrome [22].…”

Section: Risk Stratification Of Patients After Myocardial Infarctionmentioning

confidence: 90%

T-wave alternans for risk stratification and prevention of sudden cardiac death

Pruvot

Rosenbaum

2003

Curr Cardiol Rep

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Despite considerable progress in the management of ischemic heart disease, a substantial proportion of patients continue to experience life-threatening arrhythmic events. The Multicenter Automatic Defibrillator Implantation Trial 2 has recently shown the superiority of implantable cardioverter defibrillators (ICDs) over conventional strategies to prevent sudden death in patients with reduced ejection fraction, but at the expense of potentially unnecessary ICD implantation in a large percentage of patients. T-wave alternans (TWA), which reflects alternation of cellular repolarization, results in a substantial increase in dispersion of repolarization, a prerequisite for reentrant arrhythmias. Recent trials, cumulating close to 3000 patients, have established TWA analysis as a powerful tool for arrhythmia prevention. Based on the most recent estimates, at least one third of post-myocardial infarction patients are expected to be tested negative. With a negative predictive value greater than 90%, TWA might allow for targeting of patients most likely to benefit from ICD therapy. Accurate identification of high-risk patients by noninvasive TWA may allow for improved widespread screening for sudden death prevention in the general population.

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Experimentalle studien an säugethieren über das elektrocardiogramm

Cited by 69 publications

References 2 publications

T-Wave Alternans and the Susceptibility to Ventricular Arrhythmias

T-Wave Alternans and the Susceptibility to Ventricular Arrhythmias

The Dynamics of Pulsus Alternans: Alternating End-Diastolic Fiber Length as a Causative Factor

T-wave alternans for risk stratification and prevention of sudden cardiac death

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