Innovation and entrepreneurship is the soul of entrepreneurship, and realizing the integration of innovation and entrepreneurship education and collaborative experiment platform in colleges and universities is an important way to promote the development of entrepreneurship and facilitate higher quality employment. In this paper, the authors propose the 3D-IVF intelligent sensor overlay algorithm wisdom laboratory system structure and application mode through in-depth investigation of collaborative laboratory, build the macroenvironment and construction demand of collaborative experiment management platform of innovation and entrepreneurship education, comprehensively analyze the current situation, problems, and effectiveness of its integration of innovation and entrepreneurship education and professional education. In addition, we explore the operation mechanism of its organizational system, curriculum system, management system, and platform construction in the practice of integrating innovation and entrepreneurship education with professional education. The average coverage rate of the 3D-IVF-based 3D coverage algorithm is 92.15%, and the deployment time is 2.5857 s; the average coverage rate is improved by 0.76%, and the deployment time is reduced by 0.1712 s. Design FIR filter using MATLAB and Hilbert transform filter, generate HDL code, and implement it on FPGA. Use the designed low-pass and band-pass filters to filter the 100 KHz square wave signal sampled by the ADC. When the number of iterations of the algorithm reaches 30, the coverage rates of the four-node deployment strategies will stabilize, i.e., the forces between the nodes of the 3D-VF-based 3D coverage algorithm of this paper. The equilibrium state is reached. We use resources and real-time experimental data sharing to realize collaborative design among team members, further optimize the curriculum structure of innovation and entrepreneurship education, adopt diversified forms of curriculum implementation, and implement a diversified curriculum evaluation system, etc.