Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive<sup>125</sup>I seed implantation therapy

Wang, Junjie; Chai, Shude; Wang, Ruo–Yu; Zheng, Guangjun; Zhang, Kaixian; Huo, Bin; Huo, Xiaodong; Jiang, Yuliang; Ji, Zhe; Jiang, Ping; Peng, Ran

doi:10.4103/jcrt.jcrt_434_19

Cited by 17 publications

(16 citation statements)

References 20 publications

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“…Several therapeutic approaches have been conducted to try and decrease rates of restenosis [5][6][7]. Compared to the traditional external beam radiation, I-255 seed brachytherapy better shields surrounding tissues, more precisely targeting radiation to the tumor site [21].…”

Section: Discussionmentioning

confidence: 99%

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

Zhao¹,

Gu²,

Huo³

et al. 2021

Videosurgery and Other Miniinvasive Techniques

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Introduction: Malignant esophageal obstruction is usually caused by esophageal and other chest cancers. More than 80% of cases of obstructive esophageal cancer (OEC) have lost the chance of curative resection. Stent insertion is a first-line palliative approach used to treat incurable OEC. Aim: To gauge the relative clinical efficacy of I-125 seed-loaded stent (ISS) versus normal stent (NS) insertion as a treatment for OEC. Material and methods: Querying of the PubMed, Embase, and Cochrane Library databases was conducted to find all relevant studies published up to November 2020. The meta-analysis was undertaken using RevMan v5.3. Results: We identified 158 studies initially, eight (4 randomized controlled trials and 4 retrospective studies) of which were used in this meta-analysis. We found that the two groups exhibited the comparable pooled Δdysphagia scores (MD = 0.02; p = 0.80), stent restenosis rates (OR = 0.97; p = 0.89), stent migration rates (OR = 0.81; p = 0.63), severe chest pain rates (OR = 1.05; p = 0.81), hemorrhage rates (OR = 1.53; p = 0.16), aspiration pneumonia rates (OR = 0.72; p = 0.38), and fistula formation rates (OR = 1.47; p = 0.44). The pooled time-to-restenosis and survival were both significantly longer in the ISS group (p = 0.04 and < 0.0001, respectively). Significant heterogeneity was detected in the endpoints of Δdysphagia scores and survival (I 2 = 73% and 86%, respectively). Funnel plot analysis indicated an absence of publication bias related to the selected study endpoints. Conclusions: For patients with OEC, our meta-analysis indicated that ISS insertion could provide longer stent patency and survival than NS insertion.

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Section: Discussionmentioning

confidence: 99%

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

Zhao¹,

Gu²,

Huo³

et al. 2021

Videosurgery and Other Miniinvasive Techniques

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“…A combination of after-loading and 3D-PT, as previously discussed in further detail, can facilitate the delivery of SABT in HDR-BT and LDR-BT, named HDR-SABT and LDR-SABT, respectively. High radiation doses were required, typically with about 80–90 Gy for HDR-SABT [ 30 ] and 110–160 Gy for LDR-SABT [ 39 , 46 , 47 ], which may cause complete tumor ablation, although further investigations are warranted to confirm the observed anti-cancer effects. The schematic diagram of the SABT-related effect is shown in Figure 2 .…”

Section: Sabt Concept and Designmentioning

confidence: 99%

Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

Xue

Qiu

Wang

et al. 2021

Cancers

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Brachytherapy (BT), a type of focal anti-cancer radiotherapy, delivers a highly focused radiation dose to localized tumors, sparing surrounding normal tissues. Recent technological advances have helped to increase the accuracy of BT and, thus, improve BT-based cancer treatment. Stereotactic ablative brachytherapy (SABT) was designed to improve the ablative effect of radiation, which was achieved via improved image guidance, and calculation of ablative dose, shorter treatment duration, and better organ preservation. Recently collected data characterized SABT as having the potential to cure various early-stage cancers. The method provides higher tumor control rate levels that were previously achievable only by surgical resection. Notably, SABT is suitable for application with unresectable malignancies. However, the pathological assessment of SABT irradiated tumors is limited due to difficulties in specimen acquisition. Prostate, lung, liver, and gynecological cancers are the most commonly reported SABT-treated malignancies. This study will give an overview of SABT, focusing on the advances in SABT optimization, and provide insights on the future benefits of the combined application of SABT with cancer immunotherapies.

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“…Using 3D-PT assistance for small nodules' localization showed satisfied efficacy and safety and significantly simplified the localization procedure comparing with manual manipulation (9). Recently, an individualized 3D-printing template (3D-PT) was developed to facilitate I 125 RSI to improve the accuracy and optimize postoperative dosimetry (5)(6)(7)(8)(10)(11)(12)(13). A 3D-PT-assisted technique significantly simplifies the procedure, improves the accuracy of implantation with higher dose in target volume margin, fewer needles and complications, and shortens the procedure duration (9,14,15).…”

Section: Introductionmentioning

confidence: 99%

The Accuracy of Individualized 3D-Printing Template-Assisted I125 Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer

Qiu

Jiang

et al. 2021

Front. Oncol.

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PurposeTo evaluate the accuracy of individualized 3D-printing template-assisted I125 radioactive seed implantation (3D-PT assisted I125 RSI) for recurrent/metastatic head and neck cancer.Materials and MethodsFrom February 2017 to January 2020, clinical data of 41 patients (mean age, 58.5 ± 16.1 years; 28 males) with recurrent (48.8%)/metastatic (51.2%) head and neck cancer underwent individualized 3D-PT assisted I125 RSI under CT guidance in a single institute were retrospectively reviewed. Total 430 seed needles [mean, 10.5 (range 3–17) per patient] were inserted.ResultsAll seed needles were inserted manually in a single attempt with the technical success rate of 100% without major perioperative complications. The mean needle’s entrance deviation was 0.090 cm (95% Confidence Interval, 0.081–0.098). The mean intraoperative depth and angle of the needle were consistent with that of planned (6.23 ± 0.24 vs. 6.21 ± 0.24 cm, p = 0.903; 83.14 ± 3.64 vs. 83.09 ± 3.66 degrees, p = 0.985, respectively). The mean deviation between the needle’s planned and intraoperative depth and angle was 0.168 ± 0.024 cm and 1.56 ± 0.14 degrees, respectively. The postoperative dosimetry parameters, including D90, D100, V100, V150, V200, conformity index, external index, and homogeneity index, were all well-coordinated with planned dosimetry without significant difference (p = 0.515, 0.662, 0.958, 0.865, 0.872, 0.278, 0.456, and 0.989, respectively).ConclusionsWithin the limitation of this study, individualized 3D-PT assisted I125 RSI may be accurate in obtaining favorable postoperative dosimetry for patients with recurrent/metastatic head and neck cancer.Clinical Trial Registration[website], identifier [registration number].

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Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive¹²⁵I seed implantation therapy

Cited by 17 publications

References 20 publications

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

The Accuracy of Individualized 3D-Printing Template-Assisted I125 Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer

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Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive125I seed implantation therapy

Cited by 17 publications

References 20 publications

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

The Accuracy of Individualized 3D-Printing Template-Assisted I125 Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer

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Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive¹²⁵I seed implantation therapy