Expert consensus on management of metabolic disease in Chinese liver transplant recipients

Shen, Tian; Li, Zhuang; Sun, Xu; Qi, Xin; Wang, Zhi‐Hui; Li, Ruidong; Chang, Wenxiu; Yang, Jiayin; Yang, Yang; Zheng, Shusen

doi:10.3748/wjg.v26.i27.3851

Cited by 11 publications

(3 citation statements)

References 75 publications

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“…The CLTR is dedicated to the scientific analysis and evaluation of LT, links all transplant centres, contracts with the government and promotes the clinical work and scientific studies of LT. The data from the CLTR provides the essential evidence for the development of the LT clinical guidelines in China 3,4 . In 2018, to further strengthen the medical quality and data management of LT in China, the National Center for Healthcare Quality Management in Liver Transplant was established as an official organization based on the CLTR.…”

Section: Brief History Of Liver Transplantation In Chinamentioning

confidence: 99%

Liver transplantation in patients with liver failure: Twenty years of experience from China

2022

Liver International

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Liver failure means that the liver is not working well enough to perform its functions, such as synthesis, detoxification, metabolism and biotransformation. The symptoms of liver failure include jaundice, coagulopathy, hepatorenal syndrome, hepatic encephalopathy and ascites. Based on patient medical history and disease onset and progression, liver failure can be divided into four categories: acute liver failure (ALF), subacute liver failure (SALF), acute-on-chronic liver failure (ACLF) and chronic liver failure (CLF). 1 In China, the causes of liver failure mainly include infection with hepatitis viruses (mainly hepatitis B virus, HBV) and the use of alcohol and drugs. 1 Liver transplantation

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Section: Brief History Of Liver Transplantation In Chinamentioning

confidence: 99%

Liver transplantation in patients with liver failure: Twenty years of experience from China

2022

Liver International

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“…Metabolic diseases are common complications after liver transplantation and are risk factors for cardiovascular disease and death [ 101 ]. Common metabolic diseases include diabetes, hypoglycaemia, gout and osteoporosis.…”

Section: Trfs In Age-related Diseasesmentioning

confidence: 99%

tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

Yuán¹,

Li²,

He³

et al. 2021

Aging and disease

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“…With refined liver transplantation techniques and the standardization of perioperative management, the postoperative survival rate of LT recipients in China has gradually increased. A study on the medical quality of LT in China in 2018 showed that the mortality rate within 1 week after LT decreased from 3.7% in 2015 to 2.2% in 2018, and the 3-year cumulative survival rate of LT recipients with benign end-stage liver disease was 78.5%, which is excellent according to international standards (Chinese College of Transplant Doctors, and Division of Liver Transplantation Branch of Organ Transplantation, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value and Clinical Application of mNGS for Post-Liver Transplantation Infection: A Cross-Sectional Study With Case Reports

et al. 2022

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Liver transplantation is widely acknowledged as the only effective treatment for end-stage liver disease, and infection is reportedly an important cause of postoperative death. Clinical use of metagenomic next-generation sequencing (mNGS) to diagnose postoperative infection and successfully guide drug therapy remains rare. This study included patients with infectious complications after liver transplantation from July 2019 to December 2020 and was divided into three groups: pneumonia, unknown fever, and others (including hepatic failure, kidney failure, cirrhosis after LT, and other postoperative complications that predispose to infection). The mNGS sequencing was used to detect microorganisms, and the results were compared with traditional culture. We found that mNGS yielded improved sensitivity over culture (85.19 vs. 22.22%; p<0.0001) but lower specificity (35.71 vs. 89.28%; p<0.0001). Among the 48 kinds of pathogens detected, the Torque teno virus 22 (15/122) was the most common, followed by Primate erythroparvovirus 1 (13/122). The top four bacteria included Klebsiella pneumoniae (n = 8), Enterococcus faecium (n = 5), Stenotrophomonas maltophilia (n = 4), and Escherichia coli (n = 4). Aspergillus fumigatus was the most common fungus. The bronchoalveolar lavage fluid (BALF) exhibited the highest proportion of positive findings among sample types, with viral, fungal, and bacterial mixed infection being the most common (n = 6, 19.35%). Besides, using mNGS for early diagnosis of infection after liver transplantation may effectively prolong patient survival. This is the first study to explore the application value of mNGS and its comparison with traditional culture in pneumonia and other infections in post-liver transplantation patients. The simultaneous application of these two methods suggested that the Torque teno virus 22, Klebsiella pneumoniae, and the Aspergillus fumigatus are the most common pathogens of viruses, bacteria, and fungi after LT, suggesting that these pathogens may be associated with postoperative pathogen infection and patient prognosis. The mNGS technique showed distinct advantages in detecting mixed, viral, and parasitic infections in this patient population. Further studies are warranted to systematically elucidate the dynamic evolution and molecular characteristics of infection after liver transplantation.

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Expert consensus on management of metabolic disease in Chinese liver transplant recipients

Cited by 11 publications

References 75 publications

Liver transplantation in patients with liver failure: Twenty years of experience from China

Liver transplantation in patients with liver failure: Twenty years of experience from China

tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

Diagnostic Value and Clinical Application of mNGS for Post-Liver Transplantation Infection: A Cross-Sectional Study With Case Reports

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