Expert Consensus on the clinical application of Xuanfei Baidu granule

Abstract

Xuanfei Baidu granule is an effective prescription for COVID-19, which is modified from classical famous prescriptions. In order to further standardize clinician’s rational use of Xuanfei Baidu granule, enhance clinical efficacy, improve rational medication level, and let it play a more significant role, the frontline clinical experts are invited for discussion on the major functions, usage, adverse reactions, and considerations of Xuanfei Baidu granule to form the consensus. The consensus is that: Xuanfei Baidu granule has the efficacy of promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning; it can be used for the treatment of patients with mild, moderate, and heavy COVID-19 and other common upper respiratory tract infectious diseases such as influenza; acute tracheitis and bronchitis and community-acquired lower respiratory tract infectious diseases all belong to damp-toxin constraint in the lungs, Xuanfei Baidu granule can relieve cough, expectoration, and other symptoms caused by an acute exacerbation of the chronic obstructive pulmonary disease, with definite clinical efficacy and good safety. According to the principles of evidence-based medicine, this expert consensus will be updated regularly.

Two Multidimensional Chromatography/High-Resolution Mass Spectrometry Approaches Enabling the In-Depth Metabolite Characterization Simultaneously from Three Glycyrrhiza Species: Method Development, Comparison, and Integration

“…Licorice (Gan-Cao, in Chinese), derived from the Glycyrrhiza genus, is one of the frequently used ancient herbs, constituting a significant portion of both international and domestic markets . In addition to the wide utilization in clinical prescriptions in China (to balance the impacts of other medications), licorice can be a flavoring and sweetening agent applied in the food and tobacco industries.…”

Identification of Xuanfei Baidu granule constituents by liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry and its anti‐inflammatory active constituents using a lipopolysaccharide‐induced RAW264.7 cell model

“…Xuanfei Baidu (XFBD) granule is a granule dosage form of the XFBD prescription—one of three traditional Chinese medicine (TCM) prescriptions that played an important role in China's fight against coronavirus disease 2019 (COVID‐19). XFBD granule is composed of 13 medicinal materials and exhibits effects such as “promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning” (Liu et al, 2023). It can relieve symptoms of acute exacerbation of chronic obstructive pulmonary disease, such as cough and expectoration (Liu et al, 2023).…”

“…XFBD granule is composed of 13 medicinal materials and exhibits effects such as “promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning” (Liu et al, 2023). It can relieve symptoms of acute exacerbation of chronic obstructive pulmonary disease, such as cough and expectoration (Liu et al, 2023). The chemical constituents of TCM form the basis for their therapeutic effects, as it is well known that the constituents absorbed into blood circulation might cause the therapeutic effects (Wang, Pu et al, 2021; Wei et al, 2022; Xiong et al, 2022).…”

Xuanfeibaidu Granule Alleviates Coronavirus-Induced Pneumonia in Low Temperature and High Humidity Environments

“…These substances can be adapted to suit a particular patient's symptoms and needs [9] . Xuanfei Baidu granules (XFBD) is a TCM herbal medicine formulation that has been widely studied as an effective treatment of CoVs and has demonstrated a significant improvement of clinical symptoms in patients with COVID-19 [10] . In a clinical trial of 280 hospitalized patients treated with XFBD, none of the patients progressed to a serious or critical status [11] .…”