2021
DOI: 10.1002/art.41762
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Expert Perspective: Management of Refractory Inflammatory Myopathy

Abstract: The idiopathic inflammatory myopathies (IIMs) are chronic disorders characterized by inflammation in skeletal muscle but also in other organs such as the skin, lungs, joints, gastrointestinal tract, and heart. The effect of immunosuppressive treatment varies between individual patients and between organ manifestations within the same individual. Many patients respond poorly to first-line treatment with glucocorticoids and other immunosuppressive agents such as methotrexate or azathioprine, with symptoms persis… Show more

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Cited by 11 publications
(3 citation statements)
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“…Nuestro caso se definió como refractario por la persistencia de la debilidad muscular y elevación enzimática a pesar del tratamiento inmunosupresor convencional y luego de descartar otra causas que expliquen la falta de respuesta como infecciones, neoplasias u otras miopatías inflamatorias. [15][16] El pronóstico y la respuesta terapéutica es variable, el curso clínico puede ser monofásico/cíclico, recidivante/remitente o crónico/persistente, con la debilidad muscular como síntoma predominante o acompañada de erupción cutánea persistente.…”
Section: Discussionunclassified
“…Nuestro caso se definió como refractario por la persistencia de la debilidad muscular y elevación enzimática a pesar del tratamiento inmunosupresor convencional y luego de descartar otra causas que expliquen la falta de respuesta como infecciones, neoplasias u otras miopatías inflamatorias. [15][16] El pronóstico y la respuesta terapéutica es variable, el curso clínico puede ser monofásico/cíclico, recidivante/remitente o crónico/persistente, con la debilidad muscular como síntoma predominante o acompañada de erupción cutánea persistente.…”
Section: Discussionunclassified
“…Muscle weakness can be experienced in different muscle groups according to the underlying conditions. Many patients with muscle disease will have elevated levels of the muscle enzyme creatine kinase (CK), which is one of the most sensitive and widely measured among all muscle enzymes (1,33). Additionally, patients may often present with extra muscular manifestations, including musculoskeletal problems, respiratory problems, cardiovascular system, gastrointestinal system, etc.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, DM patients have protean clinical manifestations and different prognoses. 2,3 Rash was the most common initial symptom of DM. 4 Pathognomonic cutaneous lesions include heliotrope sign, Gottron's papules and Gottron's sign.…”
Section: Introductionmentioning
confidence: 99%