Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks

Harper, Justin; Avelar, Luiz Eduardo Toledo; Haddad, Alessandra; Novello, Juliana; Mest, Douglas; Guarnieri-Munia, Christine; Rice, Sean H.; Vega, Janelle; Andriopolous, Bill; Nogueria, Alessandra; Sadick, Neil S.

doi:10.36849/jdd.6180

Cited by 14 publications

(14 citation statements)

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“… 43 The increasing interest in the body treatment approach is remarkably apparent due to the number of scales published in the recent past years from 2019 to 2021 32–34 , 37 , 38 , 40 , 43–45 for buttocks/thighs, abdomen and knees in addition to the well-established ones logically concerning the neck and chest, hands and cellulite from 2008 to 2016 ( Figure 1 ). 35 , 36 , 39 , 42 , 45 , 46 , 48 , 49 , 144 Recommendations 6 , 8 , 27 , 100 and reviews 26 , 73 provide information on practices. Research on implementation on the body has also accentuated the use of product dilution according to area treated and of higher volume injected for large and depressed areas.…”

Section: Discussionmentioning

confidence: 99%

Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Christen¹

2022

CCID

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The number of aesthetic procedures performed worldwide continues to grow together with an increase in the population seeking the restoration or preservation of a youthful appearance. Requests for non-surgical body rejuvenation are increasing. Patients are looking for safe and effective minimally invasive aesthetic procedures. Soft-tissue dermal fillers can meet these expectations. Based on the beneficial outcomes of these treatments in many facial areas, a new trend is developing to target body areas. Different dermal fillers are available and include collagen stimulators initially developed to restore facial volume. Furthermore, they are associated with long-lasting efficiency, a high level of patient satisfaction and a good safety profile, with mainly minor adverse events reported. In appropriate conditions of use, they are now used for body rejuvenation in clinical practice. Their use is expanding and allows addressing various issues including volume loss, skin laxity, cellulite, striae distensae and wrinkles. This review focuses on poly-L-lactic acid (PLLA), used in the first collagen stimulator and one of the most investigated in facial and in off-facial body applications. The available published data, although still limited, are presented by body area, neck and chest, buttocks, abdomen, upper arms, thighs, knees, and hands. Key features of the concerned zones and the main clinical signs affecting the body part as well as the injection modalities are provided along with the aesthetic results. This represents the state of the art on which to base further developments necessary for optimal and safe outcomes of treatment with the PLLA-based collagen stimulators and others in this class for body rejuvenation.

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Section: Discussionmentioning

confidence: 99%

Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Christen¹

2022

CCID

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“…Harper and colleagues 22 recently reported their expert consensus recommendations on the use of the injectable biostimulator poly- l -lactic acid (PLLA) in noninvasive buttock contouring. Poly- l -lactic acid was assessed for the treatment of lower-extremity cellulite in 31 women in a randomized, placebo-controlled study.…”

Section: Current Treatments and Technologiesmentioning

confidence: 99%

Cellulite: Current Treatments, New Technology, and Clinical Management

LaTowsky¹,

Jacob

Hibler

et al. 2023

Dermatol Surg

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BACKGROUNDCellulite is a well-known concern for many women; however, treatment can prove challenging because of the complexities of cellulite etiology, the various factors contributing to its appearance, and the multitude of therapies and procedures available.OBJECTIVETo discuss current cellulite treatment options and effective clinical management.METHODSA roundtable meeting was convened to discuss and share views on current cellulite treatment options, new technologies, and clinical management. The participants' views helped guide a narrative review on this topic.RESULTSAdvanced interventions for cellulite treatment—such as physical and acoustic subcision, radiofrequency, and injectable biostimulators—are gradually being established, with accumulating evidence showing efficacy, patient satisfaction, and potentially long-lasting outcomes. Cellulite severity rating scales are necessary for assessing treatment outcomes, but these can be complex to use in clinical practice, and the majority do not include patient or clinician perspectives.CONCLUSIONWith the advent of new treatments and technologies, cosmetic surgeons and dermatologists will need to tailor their approach to each patient's needs and manage patient expectations because multimodal methods are likely to be required to address the various factors underlying cellulite appearance.

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“…9,10 These fillers are known to cause bruising as the most common side effect, in addition to swelling and induration. 9,10 Therefore, as part of post-treatment care, patients should be advised to avoid sun and ultraviolet lamp exposure until these AEs have resolved. 10 This practice may also reduce the risk of postinflammatory hyperpigmentation and/or hemosiderin deposits.…”

Section: Adverse Events Related To Injectable Treatmentsmentioning

confidence: 99%

“…9,10 Therefore, as part of post-treatment care, patients should be advised to avoid sun and ultraviolet lamp exposure until these AEs have resolved. 10 This practice may also reduce the risk of postinflammatory hyperpigmentation and/or hemosiderin deposits. Goldie and colleagues 9 (2018) published consensus recommendations on the use of CaHA and its optimal dilution for cellulite treatment; they reported that individuals with thinner, darker skin can experience more AEs if they are administered too-superficial injections of less diluted CaHA.…”

Section: Adverse Events Related To Injectable Treatmentsmentioning

confidence: 99%

Cellulite: Clinical Challenges and Future Perspectives

Shridharani

Moradi²,

Khalifian³

et al. 2023

Dermatol Surg

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BACKGROUND Existing cellulite interventions pose various clinical challenges related mostly to ecchymosis and recovery time. OBJECTIVE To discuss the current treatment options for minimizing recovery time, efficacy of these options, and investigations into possible future approaches. METHODS A roundtable meeting was convened to discuss and share views on the clinical challenges seen in the present practice of cellulite treatments along with future approaches and mitigation strategies. The participants' views helped guide a narrative review on this topic. RESULTS Cosmetic clinicians have a range of new interventions to choose from for cellulite improvement, each with different benefits and safety aspects. Bruising is a typical side effect that is seen with treatments targeting the fibrous septa, such as subcision and injectable treatments, and in some cases may produce long-lasting hyperpigmentation from postinflammatory hyperpigmentation or hemosiderin staining. Various strategies that could potentially mitigate bruising and other adverse effects of cellulite treatment are under clinical investigation, including, but not limited to, different injection techniques and dilutions, compression garments, cold packs, arnica gel, pulsed dye laser treatment, intralesional epinephrine, and tranexamic acid. CONCLUSION Clinical challenges including varying treatment outcomes and certain treatment sequelae remain, and further research is needed to prevent side effects and improve treatment outcomes.

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Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks

Cited by 14 publications

References 0 publications

Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Cellulite: Current Treatments, New Technology, and Clinical Management

Cellulite: Clinical Challenges and Future Perspectives

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