“…3 HSA, a natively a-helical globular plasma protein, is considered to be a model protein for investigating the fibrillation process due to its propensity to aggregate in vitro. 4 The fibrillation process of HSA is found to be affected by different factors such as sequential arrangement of amino acids, temperature, pH, ionic strength, dispersion media, addition of metal ions, antioxidants or surfactants, etc. [5][6][7][8][9][10] For instance, our previous study successfully demonstrated how the star-shaped nanostructure among four different morphologies of CuO showed the highest inhibition against HSA fibrillation due to the highest surface area that facilitated the maximum absorption of HSA.…”