Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

Siddiqui, Bazla; Rehman, Asim Ur; ul-Haq, Ihsan; Al‐Dossary, Amal A.; Elaı̈ssari, Abdelhamid; Ahmed, Naveed

doi:10.1016/j.ijpx.2022.100116

Cited by 30 publications

(23 citation statements)

References 222 publications

(227 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[31] This suggests that particle size may not be a function of template concentration in our case but may have been regulated by pH, reaction time and temperature which has also been described for traditional Stober's methods. [44] However, we have observed in previous studies that concentration of template may lead to increase in size for one-pot DOX silica nanoparticles. [22] The reason attributed was due to DOX loading micelles which was a result of addition of surfactant in the reaction medium.…”

Section: Chemistryselectmentioning

confidence: 86%

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

2023

View full text Add to dashboard Cite

In this study, we report doxorubicin preparation with bioactive glass‐ceramic as a novel hybrid nanoparticle formulation. Synthesis was carried out through a bio‐inspired route where different precursors of bioactive glass are added to a Tris(hydroxymethyl)aminomethane buffer adjusted to slightly alkaline pH containing doxorubicin. With increasing concentration of doxorubicin, loading increased in quantity with comparatively higher drug release in acidic pH than neutral pH. Without synthetic surfactant or high temperature calcination, bioactive glass‐ceramic nanoparticles demonstrated significantly superior cytotoxic behavior towards osteosarcoma cell line when compared to equivalent free drug or its action towards non‐cancerous cell line. The particles exhibited hydroxyapatite deposition when immersed in simulated body fluid for 7 days. The bio‐inspired route for synthesis of doxorubicin‐bioactive glass‐ceramic hybrid nanoparticles is an efficient cost ‐effective synthesis mechanismwhich is environmentally friendly without hampering the stability or activity of the drug.

show abstract

Section: Chemistryselectmentioning

confidence: 86%

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

2023

View full text Add to dashboard Cite

show abstract

“…Common SiO 2 sources used herein include tetraethyl orthosilicate (TEOS), tetramethyl orthosilicate (TMOS), tetra methoxy vinylsilane (TMVS), tetra butoxy silane (TBOS), tetrakis (2-hydroxyethyl) orthosilicate (THEOS), tetra propyl ortho-silicate (TPOS), trimethoxy silane (TMS) and sodium metasilicate (Na 2 SiO 3 ). Noted catalysts in the process include NaOH, HCl, NH 3 , diethanolamine (DEA) and triethanolamine (TEA) [ 27 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. The surfactant used in the MSNPs’ synthesis is the reason for the varied morphologies, from dispersed monospheres to agglomerates, manifested from altered TEOS hydrolysis and CTAB micellization.…”

Section: Exclusive Terminologies and Synthesis Methods Of Mesoporous ...mentioning

confidence: 99%

Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment

et al. 2023

View full text Add to dashboard Cite

Breast cancer (BC) currently occupies the second rank in cancer-related global female deaths. Although consistent awareness and improved diagnosis have reduced mortality in recent years, late diagnosis and resistant response still limit the therapeutic efficacy of chemotherapeutic drugs (CDs), leading to relapse with consequent invasion and metastasis. Treatment with CDs is indeed well-versed but it is badly curtailed with accompanying side effects and inadequacies of site-specific drug delivery. As a result, drug carriers ensuring stealth delivery and sustained drug release with improved pharmacokinetics and biodistribution are urgently needed. Core–shell mesoporous silica nanoparticles (MSNPs) have recently been a cornerstone in this context, attributed to their high surface area, low density, robust functionalization, high drug loading capacity, size–shape-controlled functioning, and homogeneous shell architecture, enabling stealth drug delivery. Recent interest in using MSNPs as drug delivery vehicles has been due to their functionalization and size–shape-driven versatilities. With such insights, this article focuses on the preparation methods and drug delivery mechanisms of MSNPs, before discussing their emerging utility in BC treatment. The information compiled herein could consolidate the database for using inorganic nanoparticles (NPs) as BC drug delivery vehicles in terms of design, application and resolving post-therapy complications.

show abstract

“…For that reason, MSNs are considered more versatile than nonporous silica NPs. Besides, MSNs could be synthesized with different shapes: sphere-like, yolk-shell, hollow and peanut-like structures, being sphere nanostructures preferred for their use as carriers (60)(61)(62)(63). Their potential use as a drug delivery system was firstly proposed by Vallet-Reg ı in 2001 (64).…”

Section: Mesoporous Silica Nanoparticles: Types Synthesis and Functio...mentioning

confidence: 99%

“…For that reason, at a low pH, the reaction time becomes very slow modifying the NP morphology and size. In this regard, different bases could be used, being the most common ammonium hydroxide (NH 4 OH) or sodium hydroxide (NaOH; [46,59,60]). 3 Alkoxide concentration.…”

Section: Mesoporous Silica Nanoparticles: Types Synthesis and Functio...mentioning

confidence: 99%

Photosensitizer‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy^†

Prieto-Montero

Arbeloa

Martínez‐Martínez

2023

Photochem & Photobiology

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) are widely known for their versatile applications. One of the most extended is as drug delivery systems for the treatment of cancer and other diseases. This review compiles the most representative examples in the last years of functionalized MSNs as photosensitizer carriers for photodynamic therapy (PDT) against cancer. Several commercially available photosensitizers (PSs) demonstrated poor solubility in an aqueous medium and insufficient selectivity for cancer tissues. The tumor specificity of PSs is a key factor for enhancing the PDT effect and at the same time reducing side effects. The use of nanoparticles and particularly MSNs, in which PS is covalently anchored or physically embedded, can overcome these limitations. For that, PS‐MSNs can be externally decorated with compounds of interest in order to act as an active target for certain cancer cells, demonstrating enhanced phototoxicity in vitro and in vivo. The objective of this review is to collect and compare different nanosystems based on PS‐MSNs pointing out their advantages in PDT against diverse types of cancers.

show abstract

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

Cited by 30 publications

References 222 publications

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment

Photosensitizer‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy^†

Contact Info

Product

Resources

About

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

Cited by 30 publications

References 222 publications

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

One‐Pot Synthesis of Doxorubicin‐Bioactive Glass‐Ceramic Hybrid Nanoparticles through a Bio‐Inspired Route for Anti‐Cancer Therapy

Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment

Photosensitizer‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy†

Contact Info

Product

Resources

About

Photosensitizer‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy^†