Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder

Kim, Ji Sun; Kang, Eun-Sook; Bahk, Yong Chun; Jang, Sung-Lee; Hong, Kyung Sue; Baek, Ji Hyun

doi:10.3389/fpsyt.2020.00124

Cited by 27 publications

(15 citation statements)

References 55 publications

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“…Additionally, NSSI was related to greater behavioral impulsivity and increased serum TNF-α levels. Therefore, frontal dysfunction associated with greater inflammation might explain the neurobiological basis of NSSI [ 58 ]. The hypothalamic-pituitary-adrenal (HPA) axis seems to be a potential mechanism that may explain the link between sleep deprivation and NSSI.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents

Tang

Wan

et al. 2021

BMC Psychiatry

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Background Previous studies have shown a positive association between sleep deprivation and non-suicidal self-injury (NSSI) among adolescents, but few studies have described the effects of oversleeping and weekend catch-up sleep on NSSI. The present study aimed to explore the nonlinear relationship between sleep duration and NSSI among Chinese adolescents. Methods Data from China’s National Adolescent Health Surveillance for the years 2014 to 2015 were collected from 15,713 students located across four provinces in China. A self-report questionnaire was used to assess sleep duration and 12-month NSSI. Binomial logistic regression models were used to examine the association between NSSI and sleep duration. The locally estimated scatter plot smoothing (LOESS) method was used to explore the associations of total NSSI number with sleep duration, and binomial regression analysis was used to test this relationship. Results About 68.5% of adolescents reported sleeping less than 8 h on weeknights, while 37.8% of adolescents slept more than 10 h per night during weekends. The 12-month prevalence rate of NSSI was 29.4%. Compared to adolescents who reported weekend catch-up sleep of 0–1 h, those who slept < 0 h (adjusted odds ratio [aOR] = 1.38, 95% Confidence Interval [95% CI]: 1.16–1.64) had a higher risk of NSSI. Males who reported ≥3 h of weekend catch-up sleep had significantly increased odds of NSSI (aOR = 1.20, 95%CI: 1.01–1.42). Notably, a positive U-shaped association was observed between the sleep duration and the total NSSI number. Conclusions The findings reveal a nonlinear relationship between sleep duration and NSSI among Chinese adolescents. Therefore, it is necessary to be vigilant and screen for sleep duration among adolescents in NSSI treatment or prevention.

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Section: Discussionmentioning

confidence: 99%

Nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents

Tang

Wan

et al. 2021

BMC Psychiatry

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“…Glutamate is the most excitatory neurotransmitter in the brain, but numerous neurotransmitter molecules work constantly to maintain the brain functioning, including cholinergic and monoaminergic (serotonin, dopamine, and noradrenaline) neurotransmitters. Neurodegeneration can result from the alterations in the balance of neurotransmitters (Arai et al, 2004;Harris et al, 2014;Kim et al, 2020;Korte-Bouws et al, 2018;Tyagi et al, 2008;Vakalopoulos, 2014). Inflammation was previously reported to alter the neurotransmitter metabolism, and thus affects frontal neuronal activity (Yamanashi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Magdy

Gamal

Samir

et al. 2021

Journal Cellular Physiology

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Inflammatory pathway and disruption in glutamate homeostasis join at the level of the glia, resulting in various neurological disorders. In vitro studies have provided evidence that membrane proteins connexions (Cxs) are involved in glutamate release, meanwhile, excitatory amino-acid transporters (EAATs) are crucial for glutamate reuptake (clearance). Moreover, pannexin-1 (Panx-1) activation is more detrimental to neurons. Their expression patterns during inflammation and the impacts of IκB kinase (IKK) inhibition, morphine, and galantamine on the inflammatory-associated glutamate imbalance remain elusive.To investigate this, rats were injected with saline or lipopolysaccharide.Thereafter, vehicles, morphine, galantamine, and BAY-117082 were administered in different groups of animals. Subsequently, electroencephalography, enzyme-linked immunosorbent assay, western blot, and histopathological examinations were carried out and various indicators of inflammation and glutamate level were determined. Parallel analysis of Cxs, Panx-1, and EAAts in the brain was performed. Our findings strengthen the concept that unregulated expressions of Cxs, Panx-1, and EAATs contribute to glutamate accumulation and neuronal cell loss. Nuclear factor-kB (NF-κB) pathway can significantly contribute to glutamate homeostasis via modulating Cxs, Panx-1, and EAATs expressions. BAY-117082, via inhibition of IkK, promoted the antiinflammatory effects of morphine as well as galantamine. We concluded that NF-κB is an important component of reshaping the expressions of Cxs, panx-1, and EAATs and the development of glutamate-induced neuronal degeneration.

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“…Additionally, NSSI was related to greater behavioral impulsivity and increased serum TNF-α level. Therefore, frontal dysfunction associated with greater in ammation might explain the neurobiological basis of NSSI [58]. The hypothalamic-pituitary-adrenal (HPA) axis seems as one potential mechanism that may explain the link between sleep deprivation and NSSI.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear Relationship between Sleep Duration and Non-suicidal Self-injurious Behaviour among Chinese Adolescents

Tang

Wan

et al. 2020

Preprint

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Background Previous researches showed a positive association between short sleep duration and non-suicidal self-injury (NSSI) among adolescents, but few studies have described the effects of oversleeping and weekend catch-up sleep duration on NSSI. The present study aims to explore the nonlinear relationship between sleep duration and NSSI among Chinese adolescents. Methods China’s National Adolescent Health Surveillance data from 2014 to 2015 were collected from 15,713 students in four provinces within China. A self-report questionnaire was used to assess sleep duration and 12-month NSSI. Binomial logistic regression models were used to examine the associations of NSSI with sleep duration. The locally estimated scatter plot smoothing (LOESS) method was used to help explore the associations of total NSSI number with sleep duration, and binomial regression analysis was used to help test this relationship. Results About 68.5% of adolescents reported sleeping less than 8 h on weeknights while 37.8% slept more than 10 h per night during weekends. The 12-month prevalence rate of NSSI was 29.4%. Compared to the weekend catch-up sleeping for 0–1 hours, those who slept < 0 hours (adjusted Odd Ratio (aOR) = 1.38, 95% Confidence Interval (95% CI): 1.16–1.64) had higher risk of NSSI. Males who reported ≥ 3 hours of weekend catch-up sleep were significantly increased odds of NSSI (aOR = 1.20, 95%CI: 1.01–1.42). Notably, the positive U-shape association was observed between the entire sleep duration and total NSSI number. Conclusions The findings reveals that the nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents. Therefore, it is necessary to be vigilant and screen for sleep duration among adolescents in NSSI treatment or prevention.

show abstract

Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder

Cited by 27 publications

References 55 publications

Nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents

Nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Nonlinear Relationship between Sleep Duration and Non-suicidal Self-injurious Behaviour among Chinese Adolescents

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