Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults

Carlson, Barbara Waag; Neelon, Virginia J.; Carlson, John R.; Hartman, Marilyn; Dogra, Sunil

doi:10.1111/j.1532-5415.2008.01672.x

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…The current study findings are consistent with our earlier report (Carlson et al, 2008) indicating that cerebral oxygenation, as defined by rcSO 2 , declines in most older adults during sleep (all but 20 adults in our current sample). Despite the disparate trends we observed in rcSO 2 , SaO 2 fell in all three groups.…”

Section: Discussionsupporting

confidence: 93%

“…Although we collected data for the entire night, we restricted our analysis to the first sleep cycle because previous studies of young adults (Madsen, 1993) found that the greatest changes in cerebral blood flow and metabolism occurred during the transition from wakefulness to NREM sleep. Additionally, our previous study found that rcSO 2 levels dropped significantly from wake baseline during the first NREM sleep cycle (Carlson et al, 2008).…”

Section: Signal Processing and Data Analysismentioning

confidence: 80%

“…Additionally, our previous study found that rcSO 2 levels dropped significantly from wake baseline during the first NREM sleep cycle (Carlson et al, 2008). …”

Section: Methodsmentioning

confidence: 90%

“…Using the same procedure as in our previous studies (Carlson, Neelon, Carlson, Hartman, & Dogra, 2005;Carlson et al, 2008), we divided the participants into groups based on whether the rcSO 2 rose during sleep or not. Figure 3 shows how the mean rcSO 2 and change from baseline rcSO 2 during sleep varied across participants.…”

Section: Patterns Of Cerebral Oxygenation During Sleep: Baseline and mentioning

confidence: 99%

“…In fact, we have previously reported age-associated differences in cerebral oxygen reserves during sleep (Carlson, Neelon, Carlson, Hartman, & Dogra, 2008). In a study of 9 old (65–84 years) and 10 young (20–40 years) adults, we showed that, though arterial oxygenation (as measured by pulse oximetry) declined by 1–2% during the first sleep cycle in both groups, the old adults spent considerably more time with SaO 2 levels less than 90% (% time asleep: 26% versus 7%).…”

Section: Introductionmentioning

confidence: 97%

See 4 more Smart Citations

Cerebrovascular Disease and Patterns of Cerebral Oxygenation During Sleep in Elders

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Biological Research For Nursing

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Purpose The aim of this descriptive exploratory study was to describe patterns of cerebral oxygen reserves during sleep and their association with cerebrovascular risk factors in elders. Methods Participants--115 elders, age 70+ years--were monitored overnight using standard polysomnography. Measures included arterial oxyhemoglobin (SaO2) and regional measures of percent cerebral oxyhemoglobin saturation (rcSO2) via cerebral oximetry. Subjects were classified based on the magnitude of change in rcSO2 from resting baseline to the end of the first non-rapid-eye-movement (NREM) period. One way ANOVA and Chi-square were used to test group differences in SaO2 and the prevalence of cerebrovascular risk factors. Findings 20 subjects (Group 1) experienced an increase in rcSO2 during sleep along with sleeping rcSO2 levels ≥ 55%; 95 subjects experienced a decline in rcSO2; 72 subjects (Group 2) had sleeping rcSO2 levels ≥ 55%; and 23 subjects had sleeping rcSO2 levels < 55% (Group 3). Although all three groups had equivalent declines in SaO2 levels during sleep, Group 3 had more cardiovascular comorbidity than Groups 1 and 2. Conclusions While SaO2 levels decline in most people during sleep, compensatory vascular responses to these drops in SaO2 are important for preventing rcSO2 from falling during sleep. Those entering sleep with lower baseline rcSO2 levels and those with greater declines in cerebral oxygenation during sleep may have greater cardiovascular burden and be at greater risk for stroke and other forms of disabling cerebrovascular disease.

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