Exploratory findings from the Reasons for Drinking Questionnaire

Zywiak, William H.; Westerberg, Verner S.; Connors, Gerard J.; Maisto, Stephen A.

doi:10.1016/s0740-5472(03)00118-1

Cited by 83 publications

(60 citation statements)

References 10 publications

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“…It has recently been shown that the extent of these frontal alterations is correlated with higher relapse probability (Rando et al, 2011). As social disturbances are highly involved in relapse (Zywiak et al, 2003;Uekermann and Daum, 2008), our results suggest that this link between frontal alterations and relapse could be partly due to this inability to regulate social problems when frontal areas are damaged; (b) altered frontocingulate functional connectivity. Several studies showed white matter abnormalities in alcohol-dependence (Pfefferbaum and Sullivan, 2005), which are correlated with higher relapse rates (Sorg et al, 2012).…”

Section: Discussionsupporting

confidence: 51%

“…Social exclusion constitutes a major relapse factor in alcoholdependence (Zywiak et al, 2003;Pescosolido et al, 2010), but it had not yet been experimentally studied, and the cerebral alterations associated with interpersonal deficits remained totally unexplored. First, the manipulation check confirmed that both groups experienced social exclusion, with similar intensities than in previous studies (Eisenberger et al, 2003;Masten et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Its cognitive and biological correlates have been explored extensively, leading to many therapeutic proposals (Johnson et al, 2003;Ross and Peselow, 2009), but the efficiency of alcohol-dependence treatment is still low, with a relapse rate around 60% within 6 months (Maisto et al, 2006). Recent proposals for improving detoxification underlined the need to use multimodal treatments combining pharmacotherapy with psychosocial interventions, and particularly to rehabilitate interpersonal impairments (Brandon et al, 2007;Swift, 2007), which constitute the main relapse factor after mid-term abstinence (Zywiak et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Maurage

Joassin

Philippot

et al. 2013

Neurophysiologie Clinique/Clinical Neurophysiology

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Alcohol-dependence is associated with cognitive and biological alterations, and also with interpersonal impairments. Although overwhelming in clinical settings and involved in relapse, these social impairments have received little attention from researchers. Particularly, brain alterations related to social exclusion have not been explored in alcohol-dependence. Our primary purpose was to determine the neural correlates of social exclusion feelings in this population. In all, 44 participants (22 abstinent alcohol-dependent patients and 22 paired controls) played a virtual game ('cyberball') during fMRI recording. They were first included by other players, then excluded, and finally re-included. Brain areas involved in social exclusion were identified and the functional connectivity between these areas was explored using psycho-physiological interactions (PPI). Results showed that while both groups presented dorsal anterior cingulate cortex (dACC) activations during social exclusion, alcohol-dependent participants exhibited increased insula and reduced frontal activations (in ventrolateral prefrontal cortex) as compared with controls. Alcohol-dependence was also associated with persistent dACC and parahippocampal gyrus activations in re-inclusion. PPI analyses showed reduced frontocingulate connectivity during social exclusion in alcohol-dependence. Alcohol-dependence is thus linked with increased activation in areas eliciting social exclusion feelings (dACC-insula), and with impaired ability to inhibit these feelings (indexed by reduced frontal activations). Altered frontal regulation thus appears implied in the interpersonal alterations observed in alcohol-dependence, which seem reinforced by impaired frontocingulate connectivity. This first exploration of the neural correlates of interpersonal problems in alcohol-dependence could initiate the development of a social neuroscience of addictive states.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Maurage

Joassin

Philippot

et al. 2013

Neurophysiologie Clinique/Clinical Neurophysiology

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“…All of the 85 clients who relapsed were at greatest risk within the first 2 months of treatment and the highest reasons for relapse in this window of time were negative affect followed by craving cued relapse (Zywiak et al, 2003). The negative reinforcement subscale has the potential to identify those individuals who may be more at risk of relapse due to craving focused on relief of negative emotional states.…”

Section: Resultsmentioning

confidence: 99%

Factor analysis and validity of a short six-item version of the Desires for Alcohol Questionnaire

Deane

Lyons

et al. 2013

Journal of Substance Abuse Treatment

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(2013). Factor analysis and validity of a short six-item version of the Desires for Alcohol Questionnaire. Journal of Substance Abuse Treatment, 44 (5), 557-564.Factor analysis and validity of a short six-item version of the Desires for Alcohol Questionnaire AbstractReductions in cravings have been associated with improved recovery from alcohol and other drug use problems. Self-report assessments of cravings provide a way of monitoring progress over the course of treatment particularly in residential settings. There is a need to develop brief craving measures suitable for repeat administration. The aim of the study was to assess the reliability and validity of a six-item version of the Desires for Alcohol Questionnaire (DAQ-6). In study 1 exploratory factor analysis involving 710 participants attending residential treatment revealed two factors: 'expectancy of negative reinforcement' and 'strong desires and intentions'. In study 2 confirmatory factor analysis replicated this factor structure in an independent sample of 116 participants. Both studies provided evidence for convergent and discriminant validity of the DAQ-6 when compared to other measures. The DAQ-6 shows promise as a brief self-report measure of cravings but the utility of the separate subscales in treatment contexts requires further research. Intentions'. In Study 2 confirmatory factor analysis replicated this factor structure in an independent sample of 116 participants. Both studies provided evidence for convergent and discriminant validity of the DAQ-6 when compared to other measures. The DAQ-6 shows promise as a brief self report measure of cravings but the utility of the separate subscales in treatment contexts requires further research.

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“…Affective disturbances indeed constitute a crucial factor in most mental diseases, and singularly in alcohol-dependence as it has been shown that emotional problems are the main reason for more than 50% of the relapse appearing during the six months after detoxification (Zywiak et al, 2003). Despite this obvious importance of emotions in clinical settings, the experimental exploration of affective impairments in alcohol-dependence has only been developed recently.…”

Section: Alcohol-dependence: the Importance Of Emotional Deficitsmentioning

confidence: 99%