Explore the Predictive Value of Peripheral Blood Cell Parameters in Refractory Mycoplasma pneumoniae Pneumonia in Children Over 6 Years Old

Ling, Yaoyao; Ning, Jing; Xu, Yongsheng

doi:10.3389/fped.2021.659677

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…Immunoglobulins are considered potent immunomodulators for various immune-mediated diseases, and it has marked activity against Mycoplasma pneumonia and provide additional protection, especially in patients who do not respond well to antibiotic therapy. Immunoglobulins have been reported to be effective in the treatment of many autoimmune and systemic inflammatory diseases [18][19][20]. Immunoglobulins have significant effects on different immune system effector cells (such as B and T lymphocytes and dendritic cells) and regulate a wide range of genes.…”

mentioning

confidence: 99%

Efficacy of Gamma Globulin Combined with Azithromycin Sequential Therapy in the Treatment of RMPP and Its Effect on Th1/Th2 Cytokine Levels

Jia

Tian

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the efficacy of gamma globulin combined with azithromycin sequential therapy in the treatment of children with refractory mycoplasma pneumonia and its effect on Th1/Th2 cytokine levels. Method. From January 2021 to January 2022, 100 children diagnosed with refractory mycoplasma pneumonia were randomly divided into 2 groups (50 cases in each one), the control group was treated with azithromycin plus comprehensive basic treatment, and the treatment group was treated with combined treatment on the basis of the control group, gamma globulin therapy; the treatment effect and cytokine levels of the two groups were compared. Results. Th1, Th2, and Th1/Th2 before treatment were not significantly different between the two groups. Th1, Th2, and Th1/Th2 in the treatment group were significantly downregulated compared with those in the control group after treatment. The levels of IgG, IgA, and IgM in the treatment group were not significantly different from those in the control group before treatment but were significantly upregulated after treatment. IL-10, IL-6, and IL-2 levels were also significantly increased in the treatment group. The disappearance time of clinical symptoms such as fever, cough, and pulmonary rales in the treatment group was significantly shorter than that in the control group, and the cure rate in the treatment group was significantly better than that in the control group. Conclusion. The clinical effect of gamma globulin combined with azithromycin sequential therapy in the treatment of children with refractory mycoplasma pneumonia is remarkable, which can reduce inflammatory factors, improve patients’ immunity, and promote disease recovery.

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confidence: 99%

Efficacy of Gamma Globulin Combined with Azithromycin Sequential Therapy in the Treatment of RMPP and Its Effect on Th1/Th2 Cytokine Levels

Jia

Tian

et al. 2022

Computational and Mathematical Methods in Medicine

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“…35 Lee et al 8 confirmed that pleural effusion is a risk factor for nonresponse to treatment or the progression of MPP in children (OR 5.127, 95% CI 1.404-18.727). YY Ling et al 13 found that pleural effusion was an independent risk factor for RMPP in children over six years of age (OR 3.023; 95% CI 1.424-6.420, P=0.004). The current study only deals with the qualitative assessment of pleural effusion and lacks a quantitative evaluation, which may affect its contribution to the early diagnosis of RMPP.…”

Section: Dovepressmentioning

confidence: 99%

“…Among predictive models, including laboratory indicators, recent studies have found that the levels of LDH and CRP 9 in the blood are the best predictors of RMPP. Some studies have also found inflammatory indicators in the blood, such as DD, 10 SF, IL-18, 11 ALB, 12 the neutrophil-to-lymphocyte ratio (NLR) and the mean platelet volume-to-lymphocyte ratio (MPVLR), 13 are suitable for predicting RMPP. Increased IL-17A in bronchoalveolar lavage fluid is an independent risk factor for RMPP.…”

Section: Introductionmentioning

confidence: 99%

A Lung Ultrasound-Based Nomogram for the Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Hospitalized Children

Liu¹,

Wang²,

Zhan³

et al. 2022

IDR

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Early diagnosis of refractory Mycoplasma pneumoniae pneumonia (RMPP) is challenging because of the lack of practical diagnostic imaging tools. Lung ultrasound (LUS) is an emerging tool for diagnosing childhood pneumonia. Hence, we evaluated the role of a nomogram combining LUS findings, clinical features, and laboratory indices in the early prediction of RMPP in children. Patients and Methods: We retrospectively analyzed 225 children with Mycoplasma pneumoniae pneumonia (MPP) admitted to our hospital between Dec 2018 and Aug 2021. Logistic regression analysis incorporated LUS findings and clinical predictors into the nomogram. Ninety patients hospitalized from Sep 2021 to Dec 2021 were used for external validation of the prediction model. Receiver operating characteristics (ROC) and calibration curves were used to evaluate the performance of the nomogram in the early diagnosis of RMPP.Results: Ultimately, Consolidation size /BSA (odds ratio (OR) 1.015, 95% confidence interval (CI) 1.536-2.446), Pleural Effusion (OR 3.551, 95% CI 1.921-15.600), LDH (OR 1.044, 95% CI 1.006-1. 021) and CRP (OR 3.293, 95% CI 1.019-1.098) were independent risk factors for the development of RMPP. The prediction model was represented visually as a nomogram. The area under the ROC curve for the predictive nomogram was 0.955 (95% CI 0.919-0.978) in the training cohort and 0.916 (95% CI 0.838-0.964) in the validation cohort. The calibration curve is close to the diagonal. Conclusion: This is the first-time lung ultrasound was added to the predicted nomogram, which can more comprehensively assess the condition and more accurately predict the occurrence of RMPP early. Therefore, this nomogram can be widely used in the early diagnosis of RMPP, especially in primary care hospitals.

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“…Currently, known laboratory indicators that can predict the severity of MPP include peripheral blood neutrophil count, Creactive protein (CRP), lactate dehydrogenase (LDH), interleukin-6, interleukin-17A, and D-dimer (9)(10)(11)(12). Models predicting poor prognosis in MPP have also been established and evaluated (6,13).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia

Li,

Gu,

Chen

et al. 2023

Front. Immunol.

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IntroductionMycoplasma pneumoniae pneumonia (MPP) may lead to various significant outcomes, such as necrotizing pneumonia(NP) and refractory MPP (RMPP). We investigated the potential of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in patients with MPP.Methods and materialsThis was a prospective study of patients with MPP who were admitted to our hospital from 2019 to 2021. Demographic and clinical data were collected from patient records and associated with the development of NP and RMPP and other outcome measures.ResultsOf the 1,401 patients with MPP included in the study, 30 (2.1%) developed NP. The NLR was an independent predictor of NP (odds ratio 1.153, 95% confidence interval 1.022–1.300, P=0.021). The probability of NP was greater in patients with a high NLR (≥1.9) than in those with a low NLR (<1.9) (P<0.001). The NLR was also an independent predictor of RMPP (odds ratio 1.246, 95% confidence interval 1.102–1.408, P<0.005). Patients with a high NLR were more likely to develop NP and RMPP and require intensive care, and had longer total fever duration, longer hospital stays, and higher hospitalization expenses than those with a low NLR (all P<0.005).DiscussionThe NLR can serve as a predictor of poor prognosis in patients with MPP. It can predict the occurrence of NP, RMPP, and other poor outcomes. The use of this indicator would allow the simple and rapid prediction of prognosis in the early stages of MPP, enabling the implementation of appropriate treatment strategies.

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Explore the Predictive Value of Peripheral Blood Cell Parameters in Refractory Mycoplasma pneumoniae Pneumonia in Children Over 6 Years Old

Cited by 17 publications

References 35 publications

Efficacy of Gamma Globulin Combined with Azithromycin Sequential Therapy in the Treatment of RMPP and Its Effect on Th1/Th2 Cytokine Levels

Efficacy of Gamma Globulin Combined with Azithromycin Sequential Therapy in the Treatment of RMPP and Its Effect on Th1/Th2 Cytokine Levels

A Lung Ultrasound-Based Nomogram for the Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Hospitalized Children

Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia

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