Exploring and Mitigating Plague for One Health Purposes

Eads, David A.; Biggins, Dean E.; Wimsatt, Jeffrey; Eisen, Rebecca J.; Hinnebusch, B. Joseph; Matchett, Marc R.; Goldberg, Amanda R.; Livieri, Travis M.; Hacker, Gregory M.; Novak, Mark G.; Buttke, Danielle; Grassel, Shaun M.; Hughes, John P; Atiku, Linda A.

doi:10.1007/s40475-022-00265-6

Cited by 4 publications

(4 citation statements)

References 163 publications

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“…Therein, Y. pestis was (and remains) lethal to a variety of mammals and functions as an ecosystem transformer ( Eads and Biggins, 2015 ). The fate of some mammal species hinges on effective plague mitigation, with accumulating evidence of negative Y. pestis effects on several imperiled species ( Biggins et al, 2010 , 2021a , b ; Matchett et al, 2010 ; Goldberg et al, 2021 , Goldberg et al, 2022 ), raising concern among ecologists and conservation biologists ( Zeppelini et al, 2016 ; Eads et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

“…For the purposes herein, we define plague epizootics within a given species as resulting in the deaths of >90% of individuals over a wide area within weeks to months ( Biggins and Eads, 2019 ). We define enzootic plague as affecting lesser proportions of individuals, while acknowledging that enzootic plague can have strong ecological impacts ( Zeppelini et al, 2016 ) with significant conservation implications ( Biggins et al, 2021b , Biggins et al, 2021a , Biggins et al, 2010 ; Matchett et al, 2010 ; Goldberg et al, 2021 , Goldberg et al, 2022 ; Eads et al, 2022a , Eads et al, 2022b ).…”

Section: Introductionmentioning

confidence: 99%

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Prairie dog responses to vector control and vaccination during an initial Yersinia pestis invasion

Eads,

Biggins,

Ramakrishnan

et al. 2024

International Journal for Parasitology: Parasites and Wildlife

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prairie dog responses to vector control and vaccination during an initial Yersinia pestis invasion

Eads,

Biggins,

Ramakrishnan

et al. 2024

International Journal for Parasitology: Parasites and Wildlife

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“…Arguably, plague – an introduced disease caused by the flea-borne bacterium Yersinia pestis – is the greatest threat to BTPDs and associated species, including the endangered black-footed ferret ( Mustela nigripes ), a specialized predator of four Cynomys species ( Eads and Biggins, 2015 ). Considerable effort is devoted to studies of BTPDs, fleas, and plague, and much remains to be learned ( Salkeld et al, 2016 ; Eads et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Estimating parasite infrapopulation size given imperfect detection: Proof-of-concept with ectoparasitic fleas on prairie dogs

Eads¹,

Huyvaert²,

Biggins³

2023

International Journal for Parasitology: Parasites and Wildlife

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“…Deltamethrin dust is the most widely used tool for protecting PDs and ferrets against flea parasitism and Y. pestis transmission (Matchett et al 2010; Biggins et al 2021), but with repeated annual treatments, fleas may evolve deltamethrin resistance (Eads et al 2018). Therefore, additional tools are needed for integrated plague mitigation (Eads et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluating Baits With Lufenuron and Nitenpyram for Flea Control on Prairie Dogs (Cynomys Spp.) to Mitigate Plague

Eads,

Castle,

Wild

et al. 2023

Journal of Wildlife Diseases

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Plague, caused by Yersinia pestis, is a widespread threat to endangered black-footed ferrets (Mustela nigripes) and their primary prey, prairie dogs (Cynomys spp.). Wildlife biologists most commonly manage plague using insecticides to control fleas, the primary vectors of Y. pestis. We tested edible baits containing the insecticides lufenuron and/or nitenpyram in prairie dogs. During a laboratory study, we treated 26 white-tailed prairie dogs (Cynomys leucurus) with lufenuron at 300 mg/kg body mass. All animals remained clinically healthy over the 9 wk monitoring period. Although serum lufenuron concentrations were >130 ppb in two treatment groups at week 1, concentrations declined to ≤60 ppb after 3 wk in non-torpid prairie dogs and after 7 wk in torpid prairie dogs. In a field experiment, we tested baits containing a combination of 75 mg lufenuron and 6 mg nitenpyram, respectively, in black-tailed prairie dogs (Cynomys ludovicianus). We uniformly distributed baits at 125 baits/ha on two plots (treated once) and 250 baits/ha on two plots (each treated twice 4.4 wk apart). Following treatments, flea abundance increased on prairie dogs and remained stable in burrows. Our findings indicate that baits containing lufenuron and nitenpyram, at the reported treatment rates, are ineffective tools for flea control on prairie dogs. Future experiments might evaluate efficacy of higher doses of lufenuron and nitenpyram, and repetitive treatments at differing intervals over time to evaluate potentially therapeutic treatments.

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Exploring and Mitigating Plague for One Health Purposes

Cited by 4 publications

References 163 publications

Prairie dog responses to vector control and vaccination during an initial Yersinia pestis invasion

Prairie dog responses to vector control and vaccination during an initial Yersinia pestis invasion

Estimating parasite infrapopulation size given imperfect detection: Proof-of-concept with ectoparasitic fleas on prairie dogs

Evaluating Baits With Lufenuron and Nitenpyram for Flea Control on Prairie Dogs (Cynomys Spp.) to Mitigate Plague

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