Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives

Du, Shanshan; Luo, Xiaoxing; An, Jing; Zhang, Zhijun; Zhang, Shaoyong; Wang, Yirong; Ding, Yan-Yan; Jiang, Wei-Qi; Zhang, Bao‐Qi; Ma, Yue; Zhou, Yong; Hu, Yongmei; Liu, Ying‐Qian

doi:10.1002/ps.7451

Cited by 7 publications

(1 citation statement)

References 34 publications

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“…Despite the vast body of scientific evidence, it has not been conclusively reported that B is necessary for both humans and animals. In fact, several BCCs, such as borates, boronates, and boronic acids, exhibited interesting biological activities, including antiviral [2], antibacterial [3,4], antifungal and antiparasitic [5,6], antioxidant [7,8], wound healing [9], anti-inflammatory [10,11], antimutagenic [12], anticancerogenic [13,14], radiobiological [15], and neuroprotective properties [16,17]. Interestingly it was found that people living in B-rich regions had less cancer incidence than the people living in B-poor regions [18].…”

Section: Introductionmentioning

confidence: 99%

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oguzkan,

Turkez,

Ugras

et al. 2023

Inorganics

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In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium 1, borenium 2, borenium 3, borinium 4, and borinium 5 compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (p > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium 1 (60.7% and 50.7%), borenium 2 (70.4% and 57.2%), borenium 3 (53.1% and 45.2%), borinium 4 (55.1% and 48.1%), and borinium 5 (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.

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Section: Introductionmentioning

confidence: 99%

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oguzkan,

Turkez,

Ugras

et al. 2023

Inorganics

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Design and synthesis aldehydes–thiourea and thiazolyl hydrazine derivatives as promising antifungal agents against Monilinia fructicola

Wang,

Yang,

Wang

et al. 2024

Pest Management Science

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BACKGROUNDFungal diseases present a significant threat to global agriculture, necessitating the development of new, safe, and effective fungicides. Existing fungicides face resistance and health risks, prompting the synthesis of novel compounds. Researchers have synthesized aldehyde‐based thiourea and thiazolyl hydrazine derivatives, evaluating their antifungal activities to identify impactful pesticide molecules.RESULTSThe results showed that most of the compounds had broad‐spectrum antifungal activity against six plant pathogenic fungi and four post‐harvest fungi. Notably, compound LN18 showed the best antifungal activity against Monilinia fructicola with a half‐maximal effective concentration (EC50) of 0.17 μg mL−1, which was better than the commercial fungicide natamycin. A structure–activity relationship (SAR) study showed that the presence of unsaturated double bonds in the structure and the length of the carbon chain were the main factors affecting antifungal activity. The presence of unsaturated double bonds and an increase in the length of the carbon chain greatly improved inhibitory activity against the tested pathogens. The preliminary mechanism study showed that LN18 could damage the integrity of the mycelial plasma membrane, leading to leakage of intracellular nucleic acid and protein. LN18 also induced an increase in the intracellular reactive oxygen species level to exert its antifungal effects. In addition, compound LN18 had a stronger antifungal effect in vivo, and better phytotoxicity than natamycin, indicating broad application prospects in agriculture.CONCLUSIONAldehydes–thiourea and thiazolyl hydrazine derivatives demonstrate remarkable antifungal efficacy against plant pathogenic and post‐harvest fungi, offering a promising avenue for commercialization as highly efficacious, cost‐effective and safe antifungal agents. © 2024 Society of Chemical Industry.

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Design, Synthesis, and Biological Evaluation of Novel Quinoline Derivatives against Phytopathogenic Bacteria Inspired from Natural Quinine Alkaloids

Qin,

Yang,

Zhang

et al. 2024

J. Agric. Food Chem.

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A series of 2-(trifluoromethyl)-4-hydroxyquinoline derivatives were designed and synthesized with introduction of the antibacterial fragment amino alcohols, and their antibacterial activity against plant phytopathogenic bacteria was evaluated for the development of quinoline bactericides. It is worth noting that compound Qa5 exhibited excellent antibacterial activity in vitro with a minimum inhibitory concentration (MIC) value of 3.12 μg/mL against Xanthomonas oryzae (Xoo). Furthermore, in vivo assays demonstrated that the protective efficacy of Qa5 against rice bacterial blight at 200 μg/mL (33.0%) was superior to that of the commercial agent bismerthiazol (18.3%), while the curative efficacy (35.0%) was comparable to that of bismerthiazol (35.7%). The antibacterial mechanisms of Qa5 indicated that it affected the activity of bacteria by inducing intracellular oxidative damage in Xoo and disrupting the integrity of the bacterial cell membrane. The above results demonstrated that the novel quinoline derivative Qa5 possessed excellent in vitro and in vivo antibacterial activity, indicating its potential as a novel green agricultural antibacterial agent.

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Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives

Cited by 7 publications

References 34 publications

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Design and synthesis aldehydes–thiourea and thiazolyl hydrazine derivatives as promising antifungal agents against Monilinia fructicola

Design, Synthesis, and Biological Evaluation of Novel Quinoline Derivatives against Phytopathogenic Bacteria Inspired from Natural Quinine Alkaloids

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