Exploring coordination preferences and biological applications of pyridyl-based organochalcogen (Se, Te) ligands

Singh, Avtar; Dhau, Jaspreet S.; Kumar, Rajeev

doi:10.1016/j.ccr.2021.214254

Cited by 33 publications

(22 citation statements)

References 153 publications

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“…Different studies have shown that several NPs including copper oxide (CuO), zinc oxide (ZnO), titanium dioxide (TiO 2) , gold (Au), silver (Ag), selenium (Se) and graphene oxide (GO) possess antiviral properties 23 – 29 , yet the underlying toxicity mechanisms are often not fully understood. To investigate if the antiviral mechanisms of these NP types may include viral disintegration, we incubated the InViS with different NP concentrations for 2 and 24 h and measured the fluorescence intensities to detect the potential release of the fluorescent R18 label.…”

Section: Resultsmentioning

confidence: 99%

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration

Furer

Clement

Herwig

et al. 2022

Sci Rep

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The COVID–19 pandemic has caused considerable interest worldwide in antiviral surfaces, and there has been a dramatic increase in the research and development of innovative material systems to reduce virus transmission in the past few years. The International Organization for Standardization (ISO) norms 18,184 and 21,702 are two standard methods to characterize the antiviral properties of porous and non-porous surfaces. However, during the last years of the pandemic, a need for faster and inexpensive characterization of antiviral material was identified. Therefore, a complementary method based on an Inactivated Virus System (InViS) was developed to facilitate the early-stage development of antiviral technologies and quality surveillance of the production of antiviral materials safely and efficiently. The InViS is loaded with a self-quenched fluorescent dye that produces a measurable increase in fluorescence when the viral envelope disintegrates. In the present work, the sensitivity of InViS to viral disintegration by known antiviral agents is demonstrated and its potential to characterize novel materials and surfaces is explored. Finally, the InViS is used to determine the fate of viral particles within facemasks layers, rendering it an interesting tool to support the development of antiviral surface systems for technical and medical applications.

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Section: Resultsmentioning

confidence: 99%

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration

Furer

Clement

Herwig

et al. 2022

Sci Rep

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“…Other gold drugs, such as aurothiomalate and aurothioglucose, or the commercially available AF analogue, chloro-(triethylphosphine)gold(I), AF-Cl [ 26 ], could be also used as promising antiviral agents. Singh et al [ 34 ] have reported a study on the antioxidant, antimicrobial, antiviral, anticancer, anti-inflammatory, and enzyme inhibitor properties of pyridyl-based organochalcogen ligands and its metal complexes. Among all, 7-Azabenzisoselenazol-3 (2H)- compounds exhibit antiviral activity against HSV-1 virus (within a range of 0.4–2.0 µg/mL) and the organoselenium Ebselen was found efficient in the treatment of SARS-CoV-2-infected Vero cells.…”

Section: Antiviral Metal-based Drugsmentioning

confidence: 99%

Metal-Based Compounds in Antiviral Therapy

et al. 2022

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In recent years, the study of metal complexes and metal-based nanomaterials has aroused particular interest, leading to the promotion of new effective systems for the abatement of various viral diseases. Starting from the analysis of chemical properties, this review focuses on the employment of metal-based nanoparticles as antiviral drugs and how this interaction leads to a substantial enhancement in antiviral activity. The use of metal-based antiviral drugs has also spread for the formulation of antiviral vaccines, thanks especially to the remarkable adjuvant activities of some of the metal complexes. In particular, the small size and inert nature of Au- and Ag-based nanoparticles have been exploited for the design of systems for antiviral drug delivery, leading to the development of specific and safe therapies that lead to a decrease in side effects.

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“…Regarding the aspects of personalized health wellness based on novel materials for diagnostic, treatment, and antibacterial performance [ 18 , [36] , [37] , [38] , [39] ], everyone should pay special attention to indoor air quality as we do for water and food quality. The health consequences in case of contaminated air are noticeably serious and now are well-explored.…”

Section: Conclusion and Viewpointmentioning

confidence: 99%

Photoelectrochemical oxidation assisted air purifiers; perspective as potential tools to control indoor SARS-CoV-2 Exposure

Kaushik

Dhau²

2022

Applied Surface Science Advances

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Exploring coordination preferences and biological applications of pyridyl-based organochalcogen (Se, Te) ligands

Cited by 33 publications

References 153 publications

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration

Metal-Based Compounds in Antiviral Therapy

Photoelectrochemical oxidation assisted air purifiers; perspective as potential tools to control indoor SARS-CoV-2 Exposure

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