Exploring Genetic Susceptibility to Fibromyalgia

Abstract

Fibromyalgia (FM) affects 1% to 5% of the population, and approximately 90% of the affected individuals are women. FM patients experience impaired quality of life and the disorder places a considerable economic burden on the medical care system. With the recognition of FM as a major health problem, many recent studies have evaluated the pathophysiology of FM. Although the etiology of FM remains unknown, it is thought to involve some combination of genetic susceptibility and environmental exposure that triggers further alterations in gene expression. Because FM shows marked familial aggregation, most previous research has focused on genetic predisposition to FM and has revealed associations between genetic factors and the development of FM, including specific gene polymorphisms involved in the serotonergic, dopaminergic, and catecholaminergic pathways. The aim of this review was to discuss the current evidence regarding genetic factors that may play a role in the development and symptom severity of FM.

Gray matter abnormalities associated with fibromyalgia: A meta-analysis of voxel-based morphometric studies

“…Fibromyalgia is currently recognized as the product of complex interactions of diverse factors including the physical, psychological, behavioral, social, genetic, neurobiological, and environmental, which complicates treatment [5,[7][8][9]. Considerable evidence suggests that the pathophysiological hallmark of fibromyalgia is sensitization of the central nervous system, although peripheral, cognitive-emotional, and interpersonal mechanisms might also be involved [8,10,11].…”

Is having O blood type a risk factor for Fibromyalgia syndrome? The importance of nutrition in Fibromyalgia syndrome

“…Since FS is a quite important health problem, there are lots of researches to identify its pathophysiology. Although its etiology is not known, people are more focused on combination of both genetic tendency which triggers gene expression and environmental exposure [5].…”

The Coexistence of Familial Mediterranean fever and Fibromyalgia Syndrome: Two Cases Reports

“…Fibromyalgia syndrome (FMS) is a clinical condition characterized by several symptoms including chronic widespread pain, sleep disturbances, cognitive functional dysregulation and fatigue and has negative effects in patient's life [3]. Its annual prevalance is 1-5%, and 90% of FMS patients are women [4]. Its etiology has not been known clearly, but psychological, neurobiological and environmental factors are considered to play a role in the development of FMS [4].…”

“…Its annual prevalance is 1-5%, and 90% of FMS patients are women [4]. Its etiology has not been known clearly, but psychological, neurobiological and environmental factors are considered to play a role in the development of FMS [4].…”