2018
DOI: 10.1101/413005
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Exploring Genetic Variation that Influences Brain Methylation in Attention-Deficit/Hyperactivity Disorder

Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder caused by an interplay of genetic and environmental factors. Epigenetics is crucial to lasting changes in gene expression in the brain. Recent studies suggest a role for DNA methylation in ADHD. We explored the contribution to ADHD of allele-specific methylation (ASM), an epigenetic mechanism that involves SNPs correlating with differential levels of DNA methylation at CpG sites. We selected 3,896 tagSNPs reported to influence met… Show more

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“…These proportions are relatively high given that depending on tissue and developmental timing, between 20–80% of CpGs are predicted to be mQTL-associated [ 32 – 35 ]. This finding was consistent with previous research into epigenetic correlates of ADHD and schizophrenia, but this is the first demonstration of this finding for OCD [ 40 , 48 , 72 ]. In the context of schizophrenia, mQTLs have been proposed as representing SNPs with a functional annotation [ 40 , 48 ].…”
Section: Discussionsupporting
confidence: 93%
“…These proportions are relatively high given that depending on tissue and developmental timing, between 20–80% of CpGs are predicted to be mQTL-associated [ 32 – 35 ]. This finding was consistent with previous research into epigenetic correlates of ADHD and schizophrenia, but this is the first demonstration of this finding for OCD [ 40 , 48 , 72 ]. In the context of schizophrenia, mQTLs have been proposed as representing SNPs with a functional annotation [ 40 , 48 ].…”
Section: Discussionsupporting
confidence: 93%