2024
DOI: 10.1021/acs.molpharmaceut.4c00354
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Exploring How Antibody Format Drives Clearance from the Brain

Kelly Schwinghamer,
Brian M. Kopec,
Ebehiremen Ayewoh
et al.

Abstract: Monoclonal antibodies (mAbs) have high binding specificity and affinity, making them attractive for treating brain diseases. However, their effectiveness is limited by poor blood-brain barrier (BBB) penetration and rapid central nervous system (CNS) clearance. Our group identified bloodbrain barrier modulator (BBBM) peptides that improved mAb penetration across the BBB into the brain. In this study, we investigated the pharmacokinetics of a mAb delivered to the brain using BBBMs after intravenous (IV) administ… Show more

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