Exploring Hyperoxia Effects in Cancer—From Perioperative Clinical Data to Potential Molecular Mechanisms

Ristescu, Irina; Tiron, Crina; Tiron, Adrian; Grigoraş, Ioana

doi:10.3390/biomedicines9091213

Cited by 5 publications

(5 citation statements)

References 130 publications

(139 reference statements)

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“… 305 To date, several reviews have been published on the use of respiratory hyperoxia in cancer therapy. 306 , 307 , 308 , 309 , 310 …”

Section: Antitumor Effects Of Hyperoxia Therapymentioning

confidence: 99%

“…305 To date, several reviews have been published on the use of respiratory hyperoxia in cancer therapy. [306][307][308][309][310] The different responses of cancer cells and normal cells to hyperoxia also provide a principle of action for hyperoxia in cancer therapy. Little attention has been given to the differences in the way normal cells and cancer cells respond to changes in oxidative stress.…”

Section: Hyperoxia Therapy In Non-pulmonary Cancermentioning

confidence: 99%

“…An antiangiogenic effect was observed after intermittent HBO treatment 305 . To date, several reviews have been published on the use of respiratory hyperoxia in cancer therapy 306–310 …”

Section: Antitumor Effects Of Hyperoxia Therapymentioning

confidence: 99%

See 2 more Smart Citations

Hypoxia signaling in cancer: Implications for therapeutic interventions

Zhuang

Liu

et al. 2023

MedComm

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Hypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy. Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells. A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. In this review, we discuss the critical role of hypoxia in tumor development, including tumor metabolism, tumor immunity, and tumor angiogenesis. The treatment methods for hypoxic TME are summarized, including hypoxia‐targeted therapy and improving oxygenation by alleviating tumor hypoxia itself. Hyperoxia therapy can be used to improve tissue oxygen partial pressure and relieve tumor hypoxia. We focus on the underlying mechanisms of hyperoxia and their impact on current cancer therapies and discuss the prospects of hyperoxia therapy in cancer treatment.

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“… 305 To date, several reviews have been published on the use of respiratory hyperoxia in cancer therapy. 306 , 307 , 308 , 309 , 310 …”

Section: Antitumor Effects Of Hyperoxia Therapymentioning

confidence: 99%

Section: Hyperoxia Therapy In Non-pulmonary Cancermentioning

confidence: 99%

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Hypoxia signaling in cancer: Implications for therapeutic interventions

Zhuang

Liu

et al. 2023

MedComm

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“…In addition, hyperoxia treatment in patients with myocardial injury promotes damage in the short term. However, clinical studies of the long-term effect on mortality have not clarified whether this occurs in a hyperoxic treatment-dependent manner [ 72 , 73 ]. As described above, when HBO is used, the oxygen pressure is higher, leading to an increase toxicity [ 37 ].…”

Section: Adverse Effects Derived From the Use Of Hyperoxiamentioning

confidence: 99%

Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System

Herrera-Campos

Zamudio-Martínez

Delgado-Bellido

et al. 2022

Cancers

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Hyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the therapeutic agent improves the efficacy of therapies such as chemotherapy. Radiotherapy efficacy has also improved, where apoptotic mechanisms seem to be implicated. Moreover, hyperoxia increases the antitumor immunity through diverse pathways, leading to an immunopermissive TME. Although hyperoxia is an approved treatment for preventing and treating hypoxemia, it has harmful side-effects. Prolonged exposure to high oxygen levels may cause acute lung injury, characterized by an exacerbated immune response, and the destruction of the alveolar–capillary barrier. Furthermore, under this situation, the high concentration of ROS may cause toxicity that will lead not only to cell death but also to an increase in chemoattractant and proinflammatory cytokine secretion. This would end in a lung leukocyte recruitment and, therefore, lung damage. Moreover, unregulated inflammation causes different consequences promoting tumor development and metastasis. This process is known as protumor inflammation, where different cell types and molecules are implicated; for instance, IL-1β has been described as a key cytokine. Although current results show benefits over cancer therapies using hyperoxia, further studies need to be conducted, not only to improve tumor regression, but also to prevent its collateral damage.

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“…In this study, there is statistically significant evidence of negative or positive comparison of GAPDH expression and CAF, neutrophil, endothelial counts in a few types of tumors, which indicate that GAPDH would be of great significance in tumor immunity. Besides, the hyperoxia signaling pathway is involved in aggressive tumor behavior (21), and the GAPDH gene contains a hypoxia response element with a hypoxia inducible factor-1 (HIF-1) transcription factor binding site. By activating HIF-1, the expression of enzymes involved in glycolysis, such as GAPDH, could be enhanced by p-AKT in cancer cells of the colon, kidney and liver (22)(23)(24).…”

Section: Disease Free Survival (Gapdh)mentioning

confidence: 99%

Research on the oncogenic role of the house-keeping gene GAPDH in human tumors

Shen¹,

Li²,

Wang³

2023

Transl Cancer Res

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Background: As an internal reference gene, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis. While increasing evidence suggests that GAPDH plays a crucial role in tumorigenesis of some cancers, no systematic analysis of GAPDH has been conducted. Here, we sought to analyze the expression of GAPDH and its oncogenic processes in pan-cancer.Methods: GAPDH was investigated in The Cancer Genome Atlas (TCGA) tumor types using several bioinformatic tools including Tumor IMmune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis (GEPIA), University of ALabama at Birmingham CANcer (UALCAN), cBio Cancer Genomics Portal (cBioPortal), and Search Tool for Recurring Instances of Neighbouring Genes (STRING)for the expression and relationships with prognosis and immune infiltration separately.Results: Through our analysis, we measured the higher expression of GAPDH across the majority of TCGA tumors. GAPDH overexpression predicts poor survival in patients with tumors expressing a high level of GAPDH. Moreover, the genetic changes in GAPDH contributed to an increased mRNA expression.Additionally, GAPDH expression was negatively correlated with immune infiltration involving cancerassociated fibroblasts, neutrophil cell and endothelial. Conclusions:The house-keeping gene GAPDH might be a promising biomarker for pan-cancer prognosis. And GAPDH is not suitable as an internal reference gene for most cancer research, whether RNA or protein analyses.

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Exploring Hyperoxia Effects in Cancer—From Perioperative Clinical Data to Potential Molecular Mechanisms

Cited by 5 publications

References 130 publications

Hypoxia signaling in cancer: Implications for therapeutic interventions

Hypoxia signaling in cancer: Implications for therapeutic interventions

Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System

Research on the oncogenic role of the house-keeping gene GAPDH in human tumors

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