A rise in contingent work, the increasing real estate costs for organizations, technological advances, and more recently, restrictions on movement emerging from the COVID-19 pandemic have resulted in a sharp increase in the number of employees working from home. These have significant implications for individuals, organizations, and society. Yet the physical work environment within the home has received little attention from scholars. Research on traditional office settings indicates that the physical environment influences a range of well-being and performance outcomes, indicating a critical need for researchers to consider the impact of the physical work environment at home. To address this issue, the authors briefly summarize the effects of the physical work environment and review existing research on working from home. They then propose directions for future research and emerging methodologies to undertake this research. Finally, they detail the practical implications that these changes bring for individuals, organizations, and society.