Exploring insertions and deletions (indels) of &amp;lt;i&amp;gt;MSRB3&amp;lt;/i&amp;gt; gene and their association with growth traits in four Chinese indigenous cattle breeds

Wu, Mingli; Li, Shipeng; Zhang, Guoliang; Fan, Yanhui; Gao, Yuan; Huang, Yongzhen; Lan, Xianyong; Lei, Chuzhao; Ma, Yun; Dang, Ruihua

doi:10.5194/aab-62-465-2019

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…Candidate gene is a useful method to investigate the association between phenotypes and genotypes, which is helpful for improving important economical traits in beef cattle [24,25,26]. Recent data have shown that effective molecular markers used in the selection of beef quality traits could bring benefits in the beef industry [27].…”

Section: Discussionmentioning

confidence: 99%

Two Novel SNPs in RET Gene Are Associated with Cattle Body Measurement Traits

Gao

Huang

Bai

et al. 2019

Animals

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Simple SummaryThe aim of this study was to identify crucial genes and markers potentially associated with cattle economic traits which would provide a basis for molecular marker-assisted breeding and assist in the genetic selection of cattle. The RET gene plays an important role in the development of the gastrointestinal nervous system, which may influence animal body measurement by nutrient absorption. However, there have been no reports on the effects of the RET gene on the body measurement traits of cattle. Two novel SNPs (c.1407A>G and c.1425C>G) were identified in this study, which were significantly associated with the body measurement of two Chinese cattle breeds (Qinchuan and Nanyang cattle). The results suggest that c.1407A>G and c.1425C>G can be used in cattle growth-related traits marker-assisted selection breeding.AbstractThe rearrangement of the transfection (RET) gene, which mediates the functions of the ganglion in the gastrointestinal tract, plays an important role in the development of the gastrointestinal nervous system. Therefore, the RET gene is a potential factor influencing animal body measurement. The aim of this study was to reveal the significant genetic variations in the bovine RET gene and investigate the relationship between genotypes and body measurement in two Chinese cattle breeds (Qinchuan and Nanyang cattle). In this study, two SNPs (c.1407A>G and c.1425C>G) were detected in the exon 7 of RET gene by sequencing. For the SNP1 and SNP2, the GG genotype was significantly associated with body height, hip height, and chest circumference in Qinchuan cattle (p < 0.05). Individuals with an AG-CC genotype showed the lowest value of all body measurement in both breeds. Our results demonstrate that the polymorphisms in the bovine RET gene were significantly associated with body measurement, which could be used as DNA marker on the marker-assisted selection (MAS) and improve the performance of beef cattle.

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Section: Discussionmentioning

confidence: 99%

Two Novel SNPs in RET Gene Are Associated with Cattle Body Measurement Traits

Gao

Huang

Bai

et al. 2019

Animals

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“…PAFAH1B1 is a highly conserved protein, and studies in mice and other domesticated animals have found that PAFAH1B1 has an important relationship with spermatogenesis and embryonic development ( 40 ). MSRB3 plays an important role in ossification and fat deposition in cattle ( 41 ). KALRN is involved in synaptic regulation ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of differentially expressed (DE) circRNA in epididymis of yak and cattleyak

Yan²,

Pan³

et al. 2023

Front. Vet. Sci.

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Circular RNAs (circRNAs), as endogenous non-coding RNA with unique closed ring structure, is closely related to animal reproduction, and understanding the expression of circRNA in yak and cattleyak epididymal tissues is of great significance for understanding cattleyak sterility. Based on this, we screened and identified the differentially expressed circRNA in the epididymis of three yaks and two cattleyak. A total of 1,298 circRNAs were identified in the epididymis of yak and cattleyak, of which 137 differentially expressed (DE) circRNAs and the functions of some of them were elucidated in this research, as well as qPCR verification to 6 circRNAs from the 137 DE circRNAs. Gene Ontology (GO) enrichment analysis suggested that DE circRNAs were mainly related to metabolic process, development process, immune system process, reproductive process, reproduction, biological adhesion and growth. COG classification analysis showed that the DE circRNAs derived genes were mainly related to replication, recombination and repair. KEGG pathway analysis suggested that DE circRNAs were mainly involved in RNA degradation. In addition, we also screened Bta-mir-103, which is a circRNA binding miRNA related to sperm activity.

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“…The MSRB3 gene is an important member of the MSL gene family, which regulates the catalyzing effect of methionine-R-sulfoxide to methionine [67]. In four indigenous cattle breeds selected in China, individual SNPs in the MSRB3 gene were associated with traits of body growth and conformation (body weight, rump height, body length, and chest width) [68,69]. The FUT8 gene encodes an enzyme that belongs to the fucosyltransferase family.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

Selionova,

Aibazov,

Sermyagin

et al. 2023

Animals

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Goats with diverse economic phenotypic traits play an important role in animal husbandry. However, the genetic mechanisms underlying complex phenotypic traits are unclear in goats. Genomic studies of variations provided a lens to identify functional genes. The work aimed to search for candidate genes related to body measurements and body weight of Karachai goats and develop an experimental PCR-RV test system for genotyping significant SNPs. Comparison of GWAS results for ages 4 and 8 months revealed 58 common SNPs for significant genotypes. 11 common SNPs were identified for body weight, 4 SNPs—for group of traits withers height, rump height, body length, 2 SNPs—for withers height and rump height, 1 SNP—for body length and chest depth. Structural annotation of genomic regions covering a window of ±0.20 Mb showed the presence of 288 genes; 52 of them had the described functions in accordance with gene ontology. The main molecular functions of proteins encoded by these genes are the regulation of transcription, cell proliferation, angiogenesis, body growth, fatty acid and lipid metabolism, nervous system development, and spermatogenesis. SNPs common to body weight and localized within a window of ±200 kb from the structural genes CRADD, HMGA2, MSRB3, FUT8, MAX, and RAB15 were selected to create a test system. The study of meat productivity after slaughter and chemical analysis of muscle tissue in Karachai goats at the age of 8 months of different genotypes according to the identified SNPs revealed that rs268269710 is the most promising for further research and use in breeding. The GG genotype is associated with a larger live weight of animals, a larger carcass yield, the content of the boneless part in it, and the ratio of protein and adipose tissue in meat preferred for dietary nutrition. These results will contribute to the genetic improvement of Karachai goats.

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Exploring insertions and deletions (indels) of <i>MSRB3</i> gene and their association with growth traits in four Chinese indigenous cattle breeds

Cited by 8 publications

References 33 publications

Two Novel SNPs in RET Gene Are Associated with Cattle Body Measurement Traits

Two Novel SNPs in RET Gene Are Associated with Cattle Body Measurement Traits

Identification and analysis of differentially expressed (DE) circRNA in epididymis of yak and cattleyak

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

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