Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using 1H NMR‐based metabolomics
Yingting Shi,
Yuxiang Wan,
Yan Sun
et al.
Abstract:The optimization of bioprocess for CHO cell culture involves careful consideration of factors such as nutrient consumption, metabolic byproduct accumulation, cell growth, and monoclonal antibody (mAb) production. Valuable insights can be obtained by understanding cellular physiology to ensure robust and efficient bioprocess. This study aims to improve our understanding of the CHO‐K1 cell metabolism using 1H NMR‐based metabolomics. Initially, the variations in culture performance and metabolic profiles under va… Show more
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