Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer

Ju, Yeongdon; Baek, Dong Hoon; Choi, Go-Eun; Jang, Aelee

doi:10.1016/j.bbadis.2024.167209

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

2024

DOI: 10.1016/j.bbadis.2024.167209

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Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer

Yeongdon Ju,

Dong Hoon Baek,

Go-Eun Choi

et al.

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Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment

Mattar,

Umutoni,

Hassan

et al. 2024

Life

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Chemotherapy-induced peripheral neuropathy (CIPN) is a major long-lasting side effect of some chemotherapy drugs, which threatens cancer survival rate. CIPN mostly affects sensory neurons and occasionally motor neurons, causing numbness, tingling, discomfort, and burning pain in the upper and lower extremities. The pathophysiology of CIPN is not completely understood; however, it is believed that chemotherapies induce peripheral neuropathy via directly damaging mitochondria, impairing the function of ion channels, triggering immunological mechanisms, and disrupting microtubules. The treatment of CIPN is a medical challenge, and there are no approved pharmacological options. Currently, duloxetine and other antidepressants, antioxidant, anti-inflammatory, and ion-channel targeted therapies are commonly used in clinics to relieve the symptoms of CIPN. Several other types of drugs, such as cannabinoids, sigma−1 receptor antagonists, and nicotinamides ribose, are being evaluated in preclinical and clinical studies. This paper summarizes the information related to the physiology of CIPN and medicines that could be used for treating this condition.

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Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment

Mattar,

Umutoni,

Hassan

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

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Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer

Cited by 1 publication

References 54 publications

Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment

Chemotherapy-Induced Peripheral Neuropathy: A Recent Update on Pathophysiology and Treatment

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