Abstract:Introduction: Recent years has witnessed major paradigm shifts in the treatment of NSCLC with the emergence of biomarkers and targeted therapies. Most importantly, ALK is a validated biomarker and its inhibition using targeted therapies have had significant effects on patients suffering from NSCLC. However, emergence of drug resistance has limited the usage of these agents in the patients. Objective: In the present objective, e-pharmacophore based virtual screening was employed to discover potent ALK inhibitor… Show more
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