2024
DOI: 10.1002/cmdc.202400297
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Exploring Novel Coumarin‐Tethered Bis‐Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations

Sanjeev Dhawan,
Ashona Singh,
Neha Manhas
et al.

Abstract: In the present study, we identified that two representative compounds (7c and 9f) of our newly synthesized coumarin‐tagged bis‐triazoles induced apoptosis in human pancreatic cells (PANC‐1) by caspase 3/7mediated pathway. Both 7c and 9f (IC50 = 7.15 ± 1.19 and 6.09 ± 0.79 µM, respectively) were found to be ~100 times superior against PANC‐1 as compared to the standard drug Gemcitabine (IC50 = >500 µM), without showing any toxicity to the normal pancreatic epithelial cells (H6C7). Molecular docking studies f… Show more

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