Exploring Orthopedic Stem-Cell Approaches for Osteoarthritis Management: Current Trends and Future Horizons

Ehioghae, Mark; Vippa, Tarun K.; Askins, Dorothy; Slusarczyk, Sonia; Bobo, Elena; Montoya, Alexis; Anderson, Danyon; Robinson, Christopher L.; Kaye, Alan D.; Urits, Ivan

doi:10.1007/s11916-023-01191-6

Cited by 4 publications

(1 citation statement)

References 63 publications

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“…Traditional approaches to physical education often rely on instructor-led demonstrations and verbal cues to teach exercise techniques and monitor student progress (Klochko and Fedorets, 2018;Flores Ferro et al, 2022). However, these methods may lack precision and real-time feedback, limiting their effectiveness in addressing individual learning needs and promoting skill acquisition (Ehioghae et al, 2024). AREMS offers a promising solution by leveraging advanced motion tracking technology to provide instantaneous feedback on exercise form and execution (Claes, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Examination of the Augmented Reality Exercise Monitoring System as an Adjunct Tool for Prospective Teacher Trainers

Omarov,

Mamutov

et al. 2024

Retos

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This study explores the effectiveness of exercise monitoring systems in improving athlete performance and motivation within educational settings. Two hypotheses were formulated and tested: one positing that the utilization of exercise monitoring systems would reduce muscle injury rates among athletes, and the other suggesting that it would increase athletes' motivation levels. The experimental design involved dividing participants into experimental and control groups, with the former utilizing the proposed exercise monitoring system and the latter employing traditional teaching methods. Assessments were conducted post-session to measure comprehension and motivation levels, with evaluation criteria focusing on the accurate identification of course components. Contrary to expectations, the results did not support the hypotheses, indicating no significant reduction in muscle injury rates or increase in motivation levels among athletes exposed to the monitoring system. These findings underscore the need for a nuanced understanding of the complex factors influencing athlete development and performance outcomes. Future research should employ rigorous methodologies and objective outcome measures to further elucidate the role of exercise monitoring systems in athlete development and optimize their integration into training programs, thus contributing to advancements in athlete performance and motivation in educational contexts. Keywords: exercise monitoring system, real-time feedback, athlete performance, innovative instructional approaches, motivation, muscle injury, educational technology, fitness training.

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Section: Introductionmentioning

confidence: 99%

Examination of the Augmented Reality Exercise Monitoring System as an Adjunct Tool for Prospective Teacher Trainers

Omarov,

Mamutov

et al. 2024

Retos

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Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy

Lin,

Huang,

Jiao

et al. 2024

Bioengineering & Transla Med

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Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration.

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Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence

Sun,

Zhai,

Han

et al. 2024

J Transl Med

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Background Mesenchymal stem cells (MSCs) have been proposed to treat osteoarthritis (OA) for many years. However, clinical outcomes have been inconsistent due to biological variation between patients, differences in tissue source and preparation of the MSCs, and type of donor (e.g. allogenic versus autologous). Here, we test the hypothesis that inconsistent clinical outcomes are related to variations in the stemness and senescence of the injected autologous adipose-derived (AD) MSCs. Methods In the prospective randomized trial, 45 knee OA patients were divided into two groups: Group 1 (n = 22) patients treated with high tibial osteotomy (HTO) alone and Group 2 (n = 23) patients treated with HTO followed by intra-articular injection of autologous AD-MSCs (HTO + AD-MSCs). MRI and X-ray were performed pre-operation and 12 months post-operation. WOMAC and VAS score were collected four times, every 6 months over a 24-month follow-up. We observed the proliferation and stemness of AD-MSCs selected from the 5 patients showing the most improvement and from the 5 patients with the least improvement, and completed further in vitro experiments including beta-galactosidase activity, reactive oxygen species and bioinformatic analysis. Results The results showed that patients treated with HTO + AD-MSCs had a significant reduction in knee OA severity as compared to patients treated with HTO alone. Moreover, we discovered that proliferation and colony forming efficiency of AD-MSCs selected from the 5 patients showing the most improvement performed significantly better than cells selected from the 5 patients with the least improvement. AD-MSCs from the patients with the most improvement also had lower amounts of senescent cells and intracellular reactive oxygen species. Conclusions Clinical outcomes of autologous AD-MSCs therapy in knee osteoarthritis are correlated with stem cell stemness and senescence. Our study highlights emerging opportunities and trends in precision medicine that could potentially improve autologous MSC-based therapies. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-024-05814-3.

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Exploring Orthopedic Stem-Cell Approaches for Osteoarthritis Management: Current Trends and Future Horizons

Cited by 4 publications

References 63 publications

Examination of the Augmented Reality Exercise Monitoring System as an Adjunct Tool for Prospective Teacher Trainers

Examination of the Augmented Reality Exercise Monitoring System as an Adjunct Tool for Prospective Teacher Trainers

Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy

Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence

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