Exploring polymorphism, stoichiometric diversity and simultaneous existence of salt and cocrystal during cocrystallization using mechanochemistry

Gogoi, Diptajyoti; Kalita, Kalyan J.; Biswakarma, Nishant; Arhangelskis, Mihails; Deka, Ramesh Ch; Thakuria, Ranjit

doi:10.1039/d3mr00022b

RSC Mechanochem.

2024

DOI: 10.1039/d3mr00022b

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Exploring polymorphism, stoichiometric diversity and simultaneous existence of salt and cocrystal during cocrystallization using mechanochemistry

Diptajyoti Gogoi,

Kalyan J. Kalita,

Nishant Biswakarma

et al.

Abstract: We demonstrate here the mechanochemical cocrystallization of trans-aconitic acid with nicotinamide that leads to formation of multicomponent crystal forms with stoichiometric diversity, polymorphism with high Z'' and simultaneous existence of...

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Tuning of a Hydrogen‐Bonded Organic Framework by Liquid‐Assisted Mechanosynthesis between Trans‐Aconitic Acid and Isonicotinamide

Gogoi,

Sasaki,

Kalita

et al. 2024

Chemistry A European J

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Cocrystallization of trans‐aconitic acid (TACA) and isonicotinamide (INA) using liquid assisted mechanochemical grinding results in a unique supramolecular hydrogen‐bonded organic framework (HOF) system encapsulating various organic solvents (liquid guest) with the formation of channel inclusion compounds. Dimension and shape of the framework is dependent on the solvent used during liquid assisted grinding (LAG). Although crystal structure of the cocrystal (TACA)•(INA)2•(H2O)@(INA)0.5 has been determined by Single Crystal X‐ray diffraction (SCXRD), crystal structures of 3 cocrystal HOFs were determined by microcrystal electron diffraction (MicroED) and synchrotron X‐ray diffraction due to lack of suitable single crystal. PXRD analysis confirms isostructurality of various host‐guest systems; whereas guest incorporation as well as stability of the HOFs were further confirmed using thermogravimetric analysis. This study demonstrates that the framework of HOFs can be tuned by varying solvent molecules used during LAG.

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Tuning of a Hydrogen‐Bonded Organic Framework by Liquid‐Assisted Mechanosynthesis between Trans‐Aconitic Acid and Isonicotinamide

Gogoi,

Sasaki,

Kalita

et al. 2024

Chemistry A European J

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show abstract

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Exploring polymorphism, stoichiometric diversity and simultaneous existence of salt and cocrystal during cocrystallization using mechanochemistry

Abstract: We demonstrate here the mechanochemical cocrystallization of trans-aconitic acid with nicotinamide that leads to formation of multicomponent crystal forms with stoichiometric diversity, polymorphism with high Z'' and simultaneous existence of...

Cited by 1 publication

References 71 publications

Tuning of a Hydrogen‐Bonded Organic Framework by Liquid‐Assisted Mechanosynthesis between Trans‐Aconitic Acid and Isonicotinamide

Tuning of a Hydrogen‐Bonded Organic Framework by Liquid‐Assisted Mechanosynthesis between Trans‐Aconitic Acid and Isonicotinamide

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