Exploring psychiatric comorbidities and their effects on quality of life in patients with temporal lobe epilepsy and juvenile myoclonic epilepsy

Ertem, Devrimsel Harika; Dırıcan, Ayten Ceyhan; Aydın, Agah; Baybaş, Sevim; Sözmen, Vedat; Öztürk, Musa; Altunkaynak, Yavuz

doi:10.1111/pcn.12499

Cited by 40 publications

(18 citation statements)

References 28 publications

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“…Epilepsy patients, including those with MTLE, experience many psychosocial problems, including depression, anxiety, and low self-esteem (Schiffer and Babigian, 1984;Tellez-Zenteno et al, 2007). Ertem et al (2017) detected comorbid psychiatric disorders in 57% of patients with MTLE. Similarly, Nogueira et al (2017) found that 39.6% of MTLE patients met diagnostic criteria for mood disorders and 34.7% of MTLE patients met diagnostic criteria for anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal neuron loss and astrogliosis in medial temporal lobe epileptic patients with mental disorders

Huang

Zeng

et al. 2019

J. Integr. Neurosci.

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Hippocampal neuron loss and reactive astrogliosis are pathological features of medial temporal lobe epilepsy. Here, the expression of hippocampal astrogliosis-associated genes are studied in subjects with medial temporal lobe epilepsy and mental disorders (such as depression, anxiety and psychiatric comorbidities). The relationship between functional changes in hippocampus astrocytes and concurrent mental disorders are discussed. Nissl staining identified medial temporal lobe epilepsyinduced neuronal loss in the CA1 region of hippocampus. Quantitative real-time polymerase chain reaction and immunofluorescence technology were used to detect hippocampus glial fibrillary acidic protein, metallothionein, and aquaporin-4. The hippocampus area of subjects with medial temporal lobe epilepsy (with or without mental disorders) were smaller than the control group. Hippocampal neuronal loss and astrogliosis were more obvious in groups of medial temporal lobe epileptic patients with mental disorders. Relative protein levels of glial fibrillary acidic protein, metallothionein-I/II, and aquaporin-4 were significantly higher in subjects with medial temporal lobe epilepsy than seen in controls. Medial temporal lobe epileptic patients with mental disorder or depression had elevated metallothionein-I/II protein level when compared to controls and medial temporal lobe epileptic patients without mental disorder. Protein levels of glial fibrillary acidic protein and aquaporin-4 in medial temporal lobe epileptic patients with mental disorders were significantly lower than that in medial temporal lobe epileptic patients with no mental disorder. It is concluded that functional changes in hippocampus astrocytes are associated with mental disorders in medial temporal lobe epileptic patients and the astrogliosis-related genes of glial fibrillary acidic protein, metallothionein-I/II and aquaporin-4, are involved in this process.

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Section: Introductionmentioning

confidence: 99%

Hippocampal neuron loss and astrogliosis in medial temporal lobe epileptic patients with mental disorders

Huang

Zeng

et al. 2019

J. Integr. Neurosci.

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“…Ertem et al assessed the effects of psychiatric comorbidity, demographic factors, and clinical features on QOL in patients with mesial temporal lobe epilepsy, juvenile myoclonic epilepsy, and healthy controls using the QOLIE-89. In their report, only psychiatric comorbidity in PWE affected QOL regardless of seizure syndrome 37 . Similar to our study, Chen et al explored the predictive factors of QOL in patients with TLE using the QOLIE-31 inventory 38 .…”

Section: Discussionmentioning

confidence: 86%

Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities

Basaran¹,

Taş

2021

Arq. Neuro-Psiquiatr.

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Background: Investigating predictive factors of reduced quality of life (QOL) of patients and their association with focal epilepsy can improve management and treatment strategies. Objective: This study aimed to investigate the relationship between affective temperaments, depression, anxiety, disease characteristics, and QOL and to explore the predictors of QOL in patients with temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). Methods: A total of 50 patients with TLE, 51 patients with ETLE, and 70 controls were enrolled. Affective temperaments were evaluated using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A). QOL was assessed by the Short-Form Health Survey (SF-36). Beck Depression Inventory and Beck Anxiety Inventory were used to explore depression and anxiety severity, respectively. Results: Compared with the controls, patients with TLE and ETLE had significantly higher scores on all TEMPS-A scales, except on hyperthymic temperament. All the SF-36 subscale scores were lower in the TLE and ETLE groups. Linear regression analysis revealed that depressive symptoms, anxiety, depressive and irritable temperament, and seizure frequency were significant predictors of QOL in TLE. Patients with ETLE with temperamental disturbances, depressive symptoms, and polytherapy had a poorer QOL. Conclusions: Affective temperaments, psychiatric disorders, and clinical factors may predict impaired QOL in patients with TLE and ETLE. Further studies are needed to identify predictors of QOL in various epilepsy subtypes.

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“…However, alterations involved in neural circuits considered as a primary suspect. In epilepsy due to abnormal functioning of brain electrical circuits have been attributed to ion channel mutations [7,8], therefore alterations in ion channel activity in relevant areas may also claimed in etiopathology of psychiatric disorders [9]. As mentioned in above case Oxcarbazepine and its metabolite 10-monohydroxy metabolite (MHD; in addition to its primary mechanism (i.e mechanism limiting the frequency of firing voltage dependent sodium channels) it might show clinically important effects on potassium channels [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Mood disorders associated with Anti Epileptics

Chavan¹

2018

PBSIJ

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Mood disorder is not only the result of chronic stress or post-traumatic stress; Neurological disorder is also a leading source of it. This review represents a case study of an epileptic individual, suggesting realigning the focus of treatment more towards its psychiatric orientations. In adulthood epilepsy, it is necessary to maintain person's quality of life that is on antiepileptics. Antidepressants in combination with AED's should be preferred line of management to maintain the balance between psychiatric well-being and epilepsy.

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Exploring psychiatric comorbidities and their effects on quality of life in patients with temporal lobe epilepsy and juvenile myoclonic epilepsy

Abstract: Our study suggests that comorbid psychiatric disorders negatively affect patients' QOL regardless of seizure syndrome. Comorbid psychiatric conditions should be determined to increase QOL in patients with epilepsy.

Cited by 40 publications

References 28 publications

Hippocampal neuron loss and astrogliosis in medial temporal lobe epileptic patients with mental disorders

Hippocampal neuron loss and astrogliosis in medial temporal lobe epileptic patients with mental disorders

Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities

Mood disorders associated with Anti Epileptics

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