Exploring the anti‐quorum sensing activity of a <scp>d</scp>‐limonene nanoemulsion for <i>Escherichia coli</i> O157:H7

Wang, Renjie; Vega, Pablo Barranco; Xu, Yanhua; Chen, Chin Yi; Irudayaraj, Joseph

doi:10.1002/jbm.a.36404

Cited by 25 publications

(18 citation statements)

References 39 publications

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“…Moreover, its long-term stability is also enhanced (Figure 5). In a recent work D-limonene was used to prevent the formation of biofilms on E.coli O157:H7 at sub-lethal doses, by blocking the quorum sensing mediated autoinducer-2 (AI-2) communication and curli-related gene expression (Wang et al, 2018).…”

Section: Micelles Liposomes and Nano-emulsionsmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

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210

107

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The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

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Section: Micelles Liposomes and Nano-emulsionsmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

Self Cite

210

107

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“…Hereby, both swimming and swarming motilities were repressed. [24] The biosynthesis of the AI-2 signal is carriedo ut through cleavage of S-ribosylhomocysteine by LuxS ( Figure 1). [25] For signal detection, AI-2 is phosphorylated and derepresses transcription of target genes through binding to LsrR.…”

Section: Inhibition Of Ai-2 Signalingmentioning

confidence: 99%

“…[78] Also, b-lactam antibiotics as inhibitors of cell-wall biosynthesis affect virulence and population behavior at concentrations below the MIC.F or example, the third-generation cephalosporin ceftazidime (22)i nhibited virulence of P. aeruginosa PAO1 and PAF97 and reduced swarming motilityb ya round8 0% at 0.9 and 3.7 mm,r espectively (Scheme 2). [80] The antibioticsc efotaxime (23), ciprofloxacin (24), chloramphenicol, and trimethoprim completely blocked swarming of the gram-negative pathogen Salmonella enterica (ser.T yphimurium) at subgrowth inhibitory concentrations of 3.5, 0.02, 6, and 3 mm,r espectively.I nc ontrast, amikacin, colistin, kanamycin,a nd tetracycline did not inhibit swarming of S. enterica (ser.T yphimurium). While cefotaxime (23), ciprofloxacin (24)a nd trimethoprim inhibited polar-chemoreceptora rray assembly of S. enterica (ser.T yphimurium) that is essential for swarming, chloramphenicol inhibited swarming by ad ecrease in flagellation (Scheme 2).…”

Section: Sub-inhibitory Concentrations Of Antibioticsmentioning

confidence: 99%

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Inhibitors of Bacterial Swarming Behavior

Rütschlin

Böttcher

2019

Chemistry A European J

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Bacteria can migrate in groups of flagella‐driven cells over semisolid surfaces. This coordinated form of motility is called swarming behavior. Swarming is associated with enhanced virulence and antibiotic resistance of various human pathogens and may be considered as favorable adaptation to the diverse challenges that microbes face in rapidly changing environments. Consequently, the differentiation of motile swarmer cells is tightly regulated and involves multi‐layered signaling networks. Controlling swarming behavior is of major interest for the development of novel anti‐infective strategies. In addition, compounds that block swarming represent important tools for more detailed insights into the molecular mechanisms of the coordination of bacterial population behavior. Over the past decades, there has been major progress in the discovery of small‐molecule modulators and mechanisms that allow selective inhibition of swarming behavior. Herein, an overview of the achievements in the field and future directions and challenges will be presented.

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“…Biofilm formation is due to bacterium-bacterium interactions, and associations with higher organisms through intercellular communication, known as quorum sensing (QS) systems [70]. It has been suggested that D-limonene NEs inhibit QS-based virulence phenotypes in E. coli, including biofilm formation, curli and exopolysaccharides production, and swimming and swarming motility [70,71]. From the obtained results it can be hypothesized that SEO alone and, to a greater extent, SEO NEs, exerted an inhibitory activity on strong biofilm producers through modulation of QS molecule production or release, preventing the achievement of the threshold concentration for biofilm development.…”

Section: Discussionmentioning

confidence: 99%

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

et al. 2021

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Satureja montana essential oil (SEO) presents a wide range of biological activities due to its high content of active phytochemicals. In order to improve the essential oil’s (EO) properties, oil in water nanoemulsions (NEs) composed of SEO and Tween-80 were prepared, characterized, and their antimicrobial and antibiofilm properties assayed against Escherichia coli strains isolated from healthy chicken. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable surfactant/oil/water ratio. Minimal inhibitory concentration and minimal bactericidal concentration of NEs, evaluated by the microdilution method, showed that the SEO NE formulation exhibited higher inhibitory effects against planktonic E. coli than SEO alone. The quantification of biofilm production in the presence of NEs, assessed by crystal violet staining and scanning electron microscopy, evidenced that sub-MIC concentrations of SEO NEs enable an efficient reduction of biofilm production by the strong producer strains. The optimized nanoemulsion formulation could ensure food safety quality, and counteract the antibiotic resistance of poultry associated E. coli, if applied/aerosolized in poultry farms.

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Exploring the anti‐quorum sensing activity of a d‐limonene nanoemulsion for Escherichia coli O157:H7

Cited by 25 publications

References 39 publications

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Inhibitors of Bacterial Swarming Behavior

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

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