Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea

Abstract

Background: Both cardiovascular health (CVH) and inflammation associated with cognition, and inflammation also associated with cardiovascular health. However, related information in the Korean population is limited. The objective of our study was to confirm the influence of inflammation on the association between CVH and cognition in cross-sectional design. Methods: Data were obtained from the Cardiovascular and Metabolic Diseases Etiology Research Center baseline study. Participants who completed fasting serum analysis, questionnaires, and cognitive function tests were included in the analysis, whereas those with a history of autoimmune disease were excluded. CVH in Ambulatory Care Research Team health index metrics, including smoking, physical activity, healthy diet, obesity, history of hypertension, and diabetes, were used to assess CVH. Cognitive function was evaluated with the Korean version of the Mini-Mental State Estimation for Dementia Screening (MMSE-DS). Inflammatory status was assessed based on a high-sensitivity C-reactive protein (hs-CRP) test. Results: Among 2,622 total participants (mean age 57.2 years; 1,792 women), 13%, 58%, and 29% had poor, intermediate, or ideal CVH, respectively. Logistic regression analysis demonstrated that CVH was significantly associated with cognitive function only in women. Stratified analysis stated that cognitive impairment due to CVH doesn't have an association with hs-CRP level. When conducted same analyses for each CVH component, the only E p u b a h e a d o f p r i n t 2 component affecting the association was hypertension history in men.Conclusions: Overall, CVH is not significantly associated with cognitive decline in the middle-aged Korean population. Also, the modifying role of inflammation was not significant in CVH and cognition.

Cardiovascular disease risk models and dementia or cognitive decline: a systematic review

“…Furthermore, global cognitive function could be acquired by calculating Z scores. Except for one study (Jeon et al, 2021), the various risk models were found to be significantly connected with a higher chance of dementia in the future. In this study, CVH levels did not correlate with early cognitive decline in the Korean study population.…”

“…Except for Framingham models, we concluded that nine specific CVD risk models may be associated with dementia and cognitive decline. Five CVD risk models were designed for a single country ( Bao-Shan et al, 2021 ; Jeon et al, 2021 ; Buawangpong et al, 2022 ; Zheng et al, 2022 ; Mun et al, 2023 ). KPS, TCVR, the China-PAR, SCORE2, and the CANHEART health index were developed to measure cardiovascular risk among Korean, Thai, Chinese, European, and Canadian populations.…”

“…Other than CANHEART, specific CVD risk models were associated with a lower risk for dementia or cognitive decline ( Covello et al, 2021 ; Jeon et al, 2021 ; Speh et al, 2021 ). CVD risk models from multiethnic cohorts were proven to predict dementia or cognitive decline in diverse race populations, such as White, H/L, Black, or Asian.…”