Exploring the Bioactive Potentials of C60-AgNPs Nano-Composites against Malignancies and Microbial Infections

Abstract

At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm−1, 1023 cm−1, 1400 cm−1 for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C60 molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C60 elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C60 endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime.

Delpinium uncinatum mediated green synthesis of AgNPs and its antioxidant, enzyme inhibitory, cytotoxic and antimicrobial potentials

“…Previous studies have shown the antioxidant activities of bioinspired AgNPs synthesized from root extract of Nepeta leucophylla, and aerial extract of Lippia nodiflora respectively [ 46 , 47 ]. [ 48 ] also reported a dose dependent antioxidant potential for C 60 -AgNPs Nanocomposites. Such promising antioxidant potential of green synthesized NPs validates their importance as novel tools against plethora of diseases.…”

In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing

“…As shown in Fig. 2 B, FTIR wave signals at 1428 cm −1 , 1181 cm −1 , 575 cm −1 and 526 cm −1 were specific signals from fullerene owing to the intramolecular vibration of C60 skeleton structure [ 29 , 35 ]. XPS spectra showed a new N1s signal at 400.0 eV and an enhanced signal at 533.0 eV in C60@PDA (Fig.…”