Exploring the concept of vigor and dys-vigor in men of 50-65 years: effects of Robuvit®

Ledda, Andrea; Hosoi, Morio; Cesarone, M. R.; Dugall, Mark; Hu, Shu; Belcaro, Gianni; Maione, Claudia; Cotellese, Roberto; Feragalli, Beatrice; Scipione, Valeria; Scipione, Claudia

doi:10.23736/s0031-0808.19.03795-9

Cited by 4 publications

(12 citation statements)

References 6 publications

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“…22 Another study on the effects of Robuvit supplementation was conducted, including 40 men between 50 and 65 years who complained of decreased general vigor. 24 The subjects reported a significant decrease in erectile dysfunction of 38% after 4 weeks, compared to the control men, who stated a decrease of only 10%. 24 The underlying mechanism of action for this effect was not elucidated yet, but the general increase of energy due to mitophagy, muscle mass increase, and enhanced ribosomal ROBUVIT protein expression could explain the ameliorated erectile function.…”

Section: Amelioration Of Erectile Functionmentioning

confidence: 81%

“…24 The subjects reported a significant decrease in erectile dysfunction of 38% after 4 weeks, compared to the control men, who stated a decrease of only 10%. 24 The underlying mechanism of action for this effect was not elucidated yet, but the general increase of energy due to mitophagy, muscle mass increase, and enhanced ribosomal ROBUVIT protein expression could explain the ameliorated erectile function. More clinical investigations are needed to confirm the results, but the current data suggest an enhancement of sexual function after Robuvit supplementation.…”

Section: Amelioration Of Erectile Functionmentioning

confidence: 81%

“…In conclusion, Robuvit supplementation was shown to improve several characteristics of dys-vigor in this study. 24 Robuvit supports energy restoration in chronically fatigued individuals. Robuvit was taken by 48 individuals presenting with signs of exhaustion in chronic fatigue syndrome.…”

Section: Increase Of Energy and Decrease Of Fatiguementioning

confidence: 98%

“…The reported improved mitochondria regeneration, enhanced ribosomal biogenesis, increased muscle mass, and the elevated antioxidant capacity caused by urolithins give a rational basis for the results of clinical trials with Robuvit, which was shown to accelerate overall energy. 8,[22][23][24] Decreased fatigue symptoms 22,23 and better sleep, 16,23,27 faster recovery after disease 7,[10][11][12]17,19,26 or surgery, 5,14 improved mood, 8,16,27 enhanced erectile function, 22,24 reinforced antioxidant defense mechanisms in periods of stress, 18 or enhanced muscle mass gain after intense exercise 6 are the effects that have been described in diverse clinical studies (Fig. 5).…”

Section: Clinical Effects Of Robuvitmentioning

confidence: 99%

“…In several clinical studies, Robuvit supplementation was shown to induce better sleep, 16,23,27 improve sport performance, 6 lowering symptoms of chronic fatigue syndrome, 22,23 enhancing burnout symptoms, 18 improving mood 8,16,27 and erectile function, 22,24 enhanced postsurgery 5,14 and disease recovery, 7,[10][11][12]17,19,26 and increase of overall energy. 8,[22][23][24] medications. 8 Fatigue and energy were semiquantitatively assessed with the ''activation-deactivation, 12-item rating scale,'' initially introduced by Thayer.…”

Section: Increase Of Energy and Decrease Of Fatiguementioning

confidence: 99%

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Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit

Weichmann

Avaltroni

Bürki

2021

Journal of Medicinal Food

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Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially known as Robuvit Ò , has been investigated in 1172 subjects in over 20 published clinical trials. The results of the clinical studies are consistent with reported effects of urolithins regarding increased mitophagy, pointing to enhanced energy capacity. The Robuvit metabolite urolithin A, B, and C levels and the number of urolithin producers were found to be increased after intake of the extract. Mitophagy is a process, which assigns energy inefficient mitochondria to disassembly, followed by reconstruction to new and more efficient replacements. This effect of Robuvit was observed in different study groups. Supplementation of Robuvit is ascribed to aid chronically fatigued or burnt-out individuals to regain higher energy and activity levels. Robuvit has been further shown to improve conditions such as renal insufficiency, liver insufficiency, mild heart failure, posttraumatic stress disorder and fatigue after surgery and facilitate recovery from mild health impairments such as flu or hangover. There are also indications that Robuvit helps improve erectile function and general loss of vigor in elderly men. Ex vivo gene expression experiments using metabolites collected from Robuvit consumers point to increased ribosomal biogenesis in endothelial, neuronal, and keratinocyte cells. Higher ribosome density accelerates the peptide production to meet protein demand, making Robuvit a potential enhancer of physical endurance and performance. A study with recreational athletes, supplemented with Robuvit daily, reported significantly increased performance in triathlon.

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Section: Amelioration Of Erectile Functionmentioning

confidence: 81%

Section: Amelioration Of Erectile Functionmentioning

confidence: 81%

Section: Increase Of Energy and Decrease Of Fatiguementioning

confidence: 98%